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10.1038/ncomms8220 http://scihub22266oqcxt.onion/10.1038/ncomms8220 C4455097!4455097 !26008852     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26008852 &cmd=llinks): Failed to open stream: HTTP request failed! 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Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo |pdf=|usr=}}{{26008852 }} gab.com Text Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26008852 #FOAvip Chemokine-guided lymphocyte positioning in tissues is crucial for normal operation of the immune system. Direct, real-time manipulation and measurement of single-cell responses to chemokines is highly desired for investigating the cell biology of lymphocyte migration in vivo. Here we report the development of the first two-photon-activatable chemokine CCL5 through efficient one-pot total chemical synthesis in milligram scale. By spatiotemporally controlled photoactivation, we show at the single-cell level that T cells perceive the directional cue without relying on PI3K activities, which are nonetheless required for persistent migration over an extended period of time. By intravital imaging, we demonstrate artificial T-cell positioning in cutaneous tissues and lymph nodes. This work establishes a general strategy to develop high-quality photo-activatable protein agents through tailor-designed caging of multiple residues and highlights the potential of photo-activatable chemokines for understanding and potential therapeutic manipulation of cell positioning and position-controlled cell behaviours in vivo. Twit Text FOAVip Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26008852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26008852 #FOAvip English Wikipedia <ref>{{Cite pmid|26008852 }}</ref> Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo #MMPMID26008852 Chen X ; Tang S ; Zheng JS ; Zhao R ; Wang ZP ; Shao W ; Chang HN ; Cheng JY ; Zhao H ; Liu L ; Qi H Nat Commun 2015[May]; 6 (ä): 7220 PMID26008852 show ga Chemokine-guided lymphocyte positioning in tissues is crucial for normal operation of the immune system. Direct, real-time manipulation and measurement of single-cell responses to chemokines is highly desired for investigating the cell biology of lymphocyte migration in vivo. Here we report the development of the first two-photon-activatable chemokine CCL5 through efficient one-pot total chemical synthesis in milligram scale. By spatiotemporally controlled photoactivation, we show at the single-cell level that T cells perceive the directional cue without relying on PI3K activities, which are nonetheless required for persistent migration over an extended period of time. By intravital imaging, we demonstrate artificial T-cell positioning in cutaneous tissues and lymph nodes. This work establishes a general strategy to develop high-quality photo-activatable protein agents through tailor-designed caging of multiple residues and highlights the potential of photo-activatable chemokines for understanding and potential therapeutic manipulation of cell positioning and position-controlled cell behaviours in vivo. |*Photochemical Processes [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Chemokine CCL5/*chemical synthesis [MESH] |Chemotaxis [MESH] |Humans [MESH] |Mice [MESH]Chemical synthesis of a two-photon-activatable chemokine and photon-gu(epmc).pdf DeepDyve Pubget Overpricing