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10.1097/PPO.0000000000000060

http://scihub22266oqcxt.onion/10.1097/PPO.0000000000000060
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C4455017!4455017!25098286
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suck abstract from ncbi

pmid25098286      Cancer+J 2014 ; 20 (4): 262-4
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  • PD-1 as an Immune Modulatory Receptor #MMPMID25098286
  • Yao S; Chen L
  • Cancer J 2014[Jul]; 20 (4): 262-4 PMID25098286show ga
  • Programmed cell death 1 (PD-1) is an inducible immune modulatory receptor. Upon interaction with its ligands B7 homolog 1 (PD-L1) and B7-DC (PD-L2), PD-1 plays important roles in negative regulation of T cell responses to antigen stimulation and maintaining peripheral tolerance. In addition to the inducible expression pattern on conventional T cells, PD-1 is also found on regulatory T cells, follicular T and B cells, and antigen-presenting cells including activated dendritic cells and monocytes. Therefore, PD-1 may have a much broader functionality than expected in negative regulation of multiple arms of immune responses. In addition to cancer therapy, the manipulation of PD-1 and its ligands may hold great promise for therapeutic applications also in autoimmune and infectious diseases.
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