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10.1002/ijc.29145 http://scihub22266oqcxt.onion/10.1002/ijc.29145 C4454501!4454501 !25137150     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25137150 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Cancer 2015 ; 136 (5 ): E219-29 Nephropedia Template TP {{tp|p=25137150 |t=2015. SDF-1? stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II |pdf=|usr=}}{{25137150 }} gab.com Text SDF-1 stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II JO: Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25137150 #FOAvip Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs through genetic or biochemical alterations. Previously, we identified mechanical distinctions between BMSCs isolated from MM patients (mBMSCs) and those present in the BM of healthy individuals (nBMSCs). These properties of mBMSC contributed to their ability to preferentially support mCSCs. To further illustrate mechanisms underlying the differences between mBMSCs and nBMSCs, here we report that (i) mBMSCs express an abnormal, constitutively high level of phosphorylated Myosin II, which leads to stiffer membrane mechanics, (ii) mBMSCs are more sensitive to SDF-1?-induced activation of MYL2 through the G(i./o)-PI3K-RhoA-ROCK-Myosin II signaling pathway, affecting Young's modulus in BMSCs and (iii) activated Myosin II confers increased cell contractile potential, leading to enhanced collagen matrix remodeling and promoting the cell-cell interaction between mCSCs and mBMSCs. Together, our findings suggest that interfering with SDF-1? signaling may serve as a new therapeutic approach for eliminating mCSCs by disrupting their interaction with mBMSCs. Twit Text FOAVip SDF-1 stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II ????Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25137150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25137150 #FOAvip English Wikipedia <ref>{{Cite pmid|25137150 }}</ref> SDF-1? stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II #MMPMID25137150 Choi DS ; Stark DJ ; Raphael RM ; Wen J ; Su J ; Zhou X ; Chang CC ; Zu Y Int J Cancer 2015[Mar]; 136 (5 ): E219-29 PMID25137150 show ga Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs through genetic or biochemical alterations. Previously, we identified mechanical distinctions between BMSCs isolated from MM patients (mBMSCs) and those present in the BM of healthy individuals (nBMSCs). These properties of mBMSC contributed to their ability to preferentially support mCSCs. To further illustrate mechanisms underlying the differences between mBMSCs and nBMSCs, here we report that (i) mBMSCs express an abnormal, constitutively high level of phosphorylated Myosin II, which leads to stiffer membrane mechanics, (ii) mBMSCs are more sensitive to SDF-1?-induced activation of MYL2 through the G(i./o)-PI3K-RhoA-ROCK-Myosin II signaling pathway, affecting Young's modulus in BMSCs and (iii) activated Myosin II confers increased cell contractile potential, leading to enhanced collagen matrix remodeling and promoting the cell-cell interaction between mCSCs and mBMSCs. Together, our findings suggest that interfering with SDF-1? signaling may serve as a new therapeutic approach for eliminating mCSCs by disrupting their interaction with mBMSCs. |Blotting, Western [MESH] |Bone Marrow/metabolism/*pathology [MESH] |Case-Control Studies [MESH] |Cell Adhesion [MESH] |Cell Proliferation [MESH] |Chemokine CXCL12/*metabolism [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Mesenchymal Stem Cells/metabolism/*pathology [MESH] |Middle Aged [MESH] |Multiple Myeloma/metabolism/*pathology [MESH] |Myosin Type II/*metabolism [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Phosphorylation [MESH] |Signal Transduction [MESH] |Tumor Cells, Cultured [MESH] |rho-Associated Kinases/*metabolism [MESH]SDF-1? stiffens myeloma bone marrow mesenchymal stromal cells through (epmc).pdf DeepDyve Pubget Overpricing