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10.1038/labinvest.2014.131 http://scihub22266oqcxt.onion/10.1038/labinvest.2014.131 C4454381!4454381!25365205     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lab+Invest 2015 ; 95 (1): 14-25 Nephropedia Template TP {{tp|p=25365205|t=2015. Regulation of autophagy by protein post-translational modification |pdf=|usr=}}{{25365205}} gab.com Text Regulation of autophagy by protein post-translational modification JO: Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=25365205 #FOAvip Autophagy is a lysosomal mediated intracellular protein degradation process that involves ~38 autophagy related genes as well as key signaling pathways that sense cellular metabolic and redox status, and plays an important role in quality control of macromolecules and organelles. As with other major cellular pathways, autophagy proteins are subject to regulatory post-translational modification. Phosphorylation is so far the most intensively studied post-translational modification in the autophagy process, followed by ubiquitination and acetylation. An interesting and new area is also now emerging, which appears to complement these more traditional mechanisms, and includes O-GlcNAcylation and redox regulation at thiol residues. Identification of the full spectrum of post-translational modifications of autophagy proteins, and determination of their impact on autophagy will be crucial for a better understanding of autophagy regulation, its deficits in diseases, and how to exploit this process for disease therapies. Twit Text FOAVip Regulation of autophagy by protein post-translational modification ????Lab Invest http://www.kidney.de/pget.php?&tw=1&pmid=25365205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25365205 #FOAvip English Wikipedia <ref>{{Cite pmid|25365205}}</ref> Regulation of autophagy by protein post-translational modification #MMPMID25365205 Wani W; Boyer-Guittaut M; Dodson M; Chatham J; Darley-Usmar V; Zhang J Lab Invest 2015[Jan]; 95 (1): 14-25 PMID25365205show ga Autophagy is a lysosomal mediated intracellular protein degradation process that involves ~38 autophagy related genes as well as key signaling pathways that sense cellular metabolic and redox status, and plays an important role in quality control of macromolecules and organelles. As with other major cellular pathways, autophagy proteins are subject to regulatory post-translational modification. Phosphorylation is so far the most intensively studied post-translational modification in the autophagy process, followed by ubiquitination and acetylation. An interesting and new area is also now emerging, which appears to complement these more traditional mechanisms, and includes O-GlcNAcylation and redox regulation at thiol residues. Identification of the full spectrum of post-translational modifications of autophagy proteins, and determination of their impact on autophagy will be crucial for a better understanding of autophagy regulation, its deficits in diseases, and how to exploit this process for disease therapies. äRegulation of autophagy by protein post-translational modification (epmc).pdf DeepDyve Pubget Overpricing