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10.1158/0008-5472.CAN-14-2465 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2465 C4454355!4454355!25858146     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2015 ; 75 (11): 2254-63 Nephropedia Template TP {{tp|p=25858146|t=2015. Hepcidin regulation in prostate and its disruption in prostate cancer |pdf=|usr=}}{{25858146}} gab.com Text Hepcidin regulation in prostate and its disruption in prostate cancer JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25858146 #FOAvip Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling. Here we report that prostate epithelial cells also synthesize hepcidin, and that synthesis and secretion of hepcidin are markedly increased in prostate cancer cells and tissue. Prostatic hepcidin functions as an autocrine hormone, decreasing cell surface ferroportin, an iron exporter, increasing intracellular iron retention, and promoting prostate cancer cell survival. Synthesis of hepcidin in prostate cancer is controlled by a unique intersection of pathways that involves BMP4/7, IL6, Wnt, and the dual BMP and Wnt antagonist, SOSTDC1. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer, and is associated with accelerated disease progression in prostate cancer patients. These results establish a new connection between iron metabolism and prostate cancer, and suggest that prostatic dysregulation of hepcidin contributes to prostate cancer growth and progression. Twit Text FOAVip Hepcidin regulation in prostate and its disruption in prostate cancer ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25858146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25858146 #FOAvip English Wikipedia <ref>{{Cite pmid|25858146}}</ref> Hepcidin regulation in prostate and its disruption in prostate cancer #MMPMID25858146 Tesfay L; Clausen KA; Kim JW; Hegde P; Wang X; Miller LD; Deng Z; Blanchette N; Arvedson T; Miranti CK; Babitt JL; Lin HY; Peehl DM; Torti FM; Torti SV Cancer Res 2015[Jun]; 75 (11): 2254-63 PMID25858146show ga Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling. Here we report that prostate epithelial cells also synthesize hepcidin, and that synthesis and secretion of hepcidin are markedly increased in prostate cancer cells and tissue. Prostatic hepcidin functions as an autocrine hormone, decreasing cell surface ferroportin, an iron exporter, increasing intracellular iron retention, and promoting prostate cancer cell survival. Synthesis of hepcidin in prostate cancer is controlled by a unique intersection of pathways that involves BMP4/7, IL6, Wnt, and the dual BMP and Wnt antagonist, SOSTDC1. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer, and is associated with accelerated disease progression in prostate cancer patients. These results establish a new connection between iron metabolism and prostate cancer, and suggest that prostatic dysregulation of hepcidin contributes to prostate cancer growth and progression. äHepcidin regulation in prostate and its disruption in prostate cancer (epmc).pdf DeepDyve Pubget Overpricing