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10.1038/cddis.2014.328 http://scihub22266oqcxt.onion/10.1038/cddis.2014.328 C4454303!4454303!25118933     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2014 ; 5 (8): e1373- Nephropedia Template TP {{tp|p=25118933|t=2014. The protease Omi regulates mitochondrial biogenesis through the GSK3?/PGC-1? pathway |pdf=|usr=}}{{25118933}} gab.com Text The protease Omi regulates mitochondrial biogenesis through the GSK3 /PGC-1 pathway JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25118933 #FOAvip Loss of the mitochondrial protease activity of Omi causes mitochondrial dysfunction, neurodegeneration with parkinsonian features and premature death in mnd2 (motor neuron degeneration 2) mice. However, the detailed mechanisms underlying this pathology remain largely unknown. Here, we report that Omi participates in the process of mitochondrial biogenesis, which has been linked to several neurodegenerative diseases. The mitochondrial biogenesis is deficit in mnd2 mice, evidenced by severe decreases of mitochondrial components, mitochondrial DNA and mitochondrial density. Omi cleaves glycogen synthase kinase 3? (GSK3?), a kinase promoting PPAR? coactivator-1? (PGC-1?) degradation, to regulate PGC-1?, a factor important for the mitochondrial biogenesis. In mnd2 mice, GSK3? abundance is increased and PGC-1? abundance is decreased significantly. Inhibition of GSK3? by SB216763 or overexpression of PGC-1? can restore mitochondrial biogenesis in mnd2 mice or Omi-knockdown N2a cells. Furthermore, there is a significant improvement of the movement ability of mnd2 mice after SB216763 treatment. Thus, our study identified Omi as a novel regulator of mitochondrial biogenesis, involving in Omi protease-deficient-induced neurodegeneration. Twit Text FOAVip The protease Omi regulates mitochondrial biogenesis through the GSK3 /PGC-1 pathway ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25118933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25118933 #FOAvip English Wikipedia <ref>{{Cite pmid|25118933}}</ref> The protease Omi regulates mitochondrial biogenesis through the GSK3?/PGC-1? pathway #MMPMID25118933 Xu R; Hu Q; Ma Q; Liu C; Wang G Cell Death Dis 2014[Aug]; 5 (8): e1373- PMID25118933show ga Loss of the mitochondrial protease activity of Omi causes mitochondrial dysfunction, neurodegeneration with parkinsonian features and premature death in mnd2 (motor neuron degeneration 2) mice. However, the detailed mechanisms underlying this pathology remain largely unknown. Here, we report that Omi participates in the process of mitochondrial biogenesis, which has been linked to several neurodegenerative diseases. The mitochondrial biogenesis is deficit in mnd2 mice, evidenced by severe decreases of mitochondrial components, mitochondrial DNA and mitochondrial density. Omi cleaves glycogen synthase kinase 3? (GSK3?), a kinase promoting PPAR? coactivator-1? (PGC-1?) degradation, to regulate PGC-1?, a factor important for the mitochondrial biogenesis. In mnd2 mice, GSK3? abundance is increased and PGC-1? abundance is decreased significantly. Inhibition of GSK3? by SB216763 or overexpression of PGC-1? can restore mitochondrial biogenesis in mnd2 mice or Omi-knockdown N2a cells. Furthermore, there is a significant improvement of the movement ability of mnd2 mice after SB216763 treatment. Thus, our study identified Omi as a novel regulator of mitochondrial biogenesis, involving in Omi protease-deficient-induced neurodegeneration. äThe protease Omi regulates mitochondrial biogenesis through the GSK3?/(epmc).pdf DeepDyve Pubget Overpricing