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10.1038/cddis.2014.297 http://scihub22266oqcxt.onion/10.1038/cddis.2014.297 C4454295!4454295 !25118927     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25118927 &cmd=llinks): Failed to open stream: HTTP request failed! 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Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-?-mediated signaling |pdf=|usr=}}{{25118927 }} gab.com Text Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1- -mediated signaling JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25118927 #FOAvip Paclitaxel is one of the most effective chemotherapy drugs for advanced cervical cancer. However, acquired resistance of paclitaxel represents a major barrier to successful anticancer treatment. In this study, paclitaxel-resistant HeLa sublines (HeLa-R cell lines) were established by continuous exposure and increased autophagy level was observed in HeLa-R cells. 3-Methyladenine or ATG7 siRNA, autophagy inhibitors, could restore sensitivity of HeLa-R cells to paclitaxel compared with parental HeLa cells. To determine the underlying molecular mechanism, differentially expressed proteins between HeLa and HeLa-R cells were identified by two-dimensional gel electrophoresis coupled with electrospray ionization quadrupole time-of-flight MS/MS. We found glycolysis-associated proteins were upregulated in HeLa-R cell lines. Inhibition of glycolysis by 2-deoxy-D-glucose or koningic acid could decrease autophagy and enhance sensitivity of HeLa-R cells to paclitaxel. Moreover, glycolysis could activate HIF1-?. Downregulation of HIF1-? by specific siRNA could decrease autophagy and resensitize HeLa-R cells to paclitaxel. Taken together, a possible Warburg effect activated HIF1-?-mediated signaling-induced autophagic pathway is proposed, which may provide new insight into paclitaxel chemoresistance. Twit Text FOAVip Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1- -mediated signaling ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=25118927 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25118927 #FOAvip English Wikipedia <ref>{{Cite pmid|25118927 }}</ref> Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-?-mediated signaling #MMPMID25118927 Peng X ; Gong F ; Chen Y ; Jiang Y ; Liu J ; Yu M ; Zhang S ; Wang M ; Xiao G ; Liao H Cell Death Dis 2014[Aug]; 5 (8 ): e1367 PMID25118927 show ga Paclitaxel is one of the most effective chemotherapy drugs for advanced cervical cancer. However, acquired resistance of paclitaxel represents a major barrier to successful anticancer treatment. In this study, paclitaxel-resistant HeLa sublines (HeLa-R cell lines) were established by continuous exposure and increased autophagy level was observed in HeLa-R cells. 3-Methyladenine or ATG7 siRNA, autophagy inhibitors, could restore sensitivity of HeLa-R cells to paclitaxel compared with parental HeLa cells. To determine the underlying molecular mechanism, differentially expressed proteins between HeLa and HeLa-R cells were identified by two-dimensional gel electrophoresis coupled with electrospray ionization quadrupole time-of-flight MS/MS. We found glycolysis-associated proteins were upregulated in HeLa-R cell lines. Inhibition of glycolysis by 2-deoxy-D-glucose or koningic acid could decrease autophagy and enhance sensitivity of HeLa-R cells to paclitaxel. Moreover, glycolysis could activate HIF1-?. Downregulation of HIF1-? by specific siRNA could decrease autophagy and resensitize HeLa-R cells to paclitaxel. Taken together, a possible Warburg effect activated HIF1-?-mediated signaling-induced autophagic pathway is proposed, which may provide new insight into paclitaxel chemoresistance. |Adenine/analogs & derivatives/pharmacology [MESH] |Antineoplastic Agents, Phytogenic/*toxicity [MESH] |Autophagy-Related Protein 7 [MESH] |Autophagy/*drug effects [MESH] |Deoxyglucose/pharmacology [MESH] |Down-Regulation/drug effects [MESH] |Drug Resistance, Neoplasm [MESH] |Female [MESH] |Glycolysis/drug effects [MESH] |HeLa Cells [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism [MESH] |Microtubule-Associated Proteins/metabolism [MESH] |Paclitaxel/*toxicity [MESH] |RNA Interference [MESH] |Sesquiterpenes/pharmacology [MESH] |Signal Transduction/*drug effects [MESH] |Ubiquitin-Activating Enzymes/antagonists & inhibitors/genetics/metabolism [MESH] |Up-Regulation/drug effects [MESH]Autophagy promotes paclitaxel resistance of cervical cancer cells: inv(epmc).pdf DeepDyve Pubget Overpricing