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10.1038/ncomms6998

http://scihub22266oqcxt.onion/10.1038/ncomms6998
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C4454288!4454288!25601659
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suck abstract from ncbi


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pmid25601659      Nat+Commun 2015 ; 6 (ä): 5998
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  • Comprehensive Bio-Imaging with Fluorinated Nanoparticles Using Breathable Liquids #MMPMID25601659
  • Kurczy ME; Zhu ZJ; Ivanisevic J; Schuyler AM; Lalwani K; Santidrian AF; David JW; Giddabasappa A; Roberts A; Olivos HJ; O'Brien PJ; Franco L; Fields MW; Paris LP; Friedlander M; Johnson CH; Epstein A; Gendleman HE; Wood M; Felding-Habermann B; Patti GJ; Spilker ME; Siuzdak G
  • Nat Commun 2015[]; 6 (ä): 5998 PMID25601659show ga
  • Fluorocarbons are lipophobic and non-polar molecules that exhibit remarkable bio-compatibility, with applications in liquid ventilation and synthetic blood. The unique properties of these compounds have also enabled mass spectrometry imaging of tissues where the fluorocarbons act as a Teflon-like coating for nanostructured surfaces to assist in desorption/ionization. Here we report fluorinated gold nanoparticles (f-AuNPs) designed to facilitate nanostructure imaging mass spectrometry. Irradiation of f-AuNPs results in the release of the fluorocarbon ligands providing a driving force for analyte desorption. The f-AuNPs allow for the mass spectrometry analysis of both lipophilic and polar (central carbon) metabolites. An important property of AuNPs is that they also act as contrast agents for X-ray microtomography and electron microscopy, a feature we have exploited by infusing f-AuNPs into tissue via fluorocarbon liquids to facilitate multi-modal (molecular and anatomical) imaging.
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