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10.1091/mbc.E13-10-0594 http://scihub22266oqcxt.onion/10.1091/mbc.E13-10-0594 C4454169!4454169!25823928     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Cell 2015 ; 26 (7): 1207-10 Nephropedia Template TP {{tp|p=25823928|t=2015. Dynamic instability 30 years later: complexities in microtubule growth and catastrophe |pdf=|usr=}}{{25823928}} gab.com Text Dynamic instability 30 years later: complexities in microtubule growth and catastrophe JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25823928 #FOAvip Microtubules are not like other polymers. Whereas polymers such as F-actin will grow continuously as long as the subunit concentration is high enough, a steadily growing microtubule can suddenly shrink even when there is ample ??-tubulin around. This remarkable behavior was discovered in 1984 when Tim Mitchison and Marc Kirschner deduced that microtubules switch from growth to shrinkage when they lose their GTP caps. Here, I review the canonical explanation of dynamic instability that was fleshed out in the years after its discovery. Many aspects of this explanation have been recently subverted, particularly those related to how GTP-tubulin forms polymers and why GTP hydrolysis disrupts them. I describe these developments and speculate on how our explanation of dynamic instability can be changed to accommodate them. Twit Text FOAVip Dynamic instability 30 years later: complexities in microtubule growth and catastrophe ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25823928 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25823928 #FOAvip English Wikipedia <ref>{{Cite pmid|25823928}}</ref> Dynamic instability 30 years later: complexities in microtubule growth and catastrophe #MMPMID25823928 Brouhard GJ Mol Biol Cell 2015[Apr]; 26 (7): 1207-10 PMID25823928show ga Microtubules are not like other polymers. Whereas polymers such as F-actin will grow continuously as long as the subunit concentration is high enough, a steadily growing microtubule can suddenly shrink even when there is ample ??-tubulin around. This remarkable behavior was discovered in 1984 when Tim Mitchison and Marc Kirschner deduced that microtubules switch from growth to shrinkage when they lose their GTP caps. Here, I review the canonical explanation of dynamic instability that was fleshed out in the years after its discovery. Many aspects of this explanation have been recently subverted, particularly those related to how GTP-tubulin forms polymers and why GTP hydrolysis disrupts them. I describe these developments and speculate on how our explanation of dynamic instability can be changed to accommodate them. äDynamic instability 30 years later: complexities in microtubule growth(epmc).pdf DeepDyve Pubget Overpricing