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10.1038/bjc.2014.259 http://scihub22266oqcxt.onion/10.1038/bjc.2014.259 C4453837!4453837!24853181     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 2014 ; 111 (6): 1054-9 Nephropedia Template TP {{tp|p=24853181|t=2014. Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells |pdf=|usr=}}{{24853181}} gab.com Text Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=24853181 #FOAvip In addition to the properties of self-renewal and multipotency, stem cells are characterised by their distinct cell cycle status. Somatic stem cells are maintained in a quiescent state but switch reversibly from quiescence to proliferation as needed. On the other hand, embryonic stem cells and induced pluripotent stem cells proliferate rapidly until the induction of differentiation results in inhibition of cell cycle progression. Uncovering the mechanisms underlying cell cycle control in stem cells should thus provide insight into regulation of the balance between self-renewal and differentiation, a key goal of stem cell biology. Recent research has shown that cancer-initiating cells (CICs), a cell population with stem cell-like properties in cancer, are also quiescent, with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of the mechanisms of CIC quiescence might therefore be expected to provide a basis for the eradication of cancer. This review summarises our current understanding of the role of F-box and WD40 repeat domain-containing 7 (Fbxw7), a key regulator of the cell cycle, in the maintenance of normal stem cells and CICs, as well as attempts to define future challenges in this field. Twit Text FOAVip Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=24853181 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24853181 #FOAvip English Wikipedia <ref>{{Cite pmid|24853181}}</ref> Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells #MMPMID24853181 Takeishi S; Nakayama KI Br J Cancer 2014[Sep]; 111 (6): 1054-9 PMID24853181show ga In addition to the properties of self-renewal and multipotency, stem cells are characterised by their distinct cell cycle status. Somatic stem cells are maintained in a quiescent state but switch reversibly from quiescence to proliferation as needed. On the other hand, embryonic stem cells and induced pluripotent stem cells proliferate rapidly until the induction of differentiation results in inhibition of cell cycle progression. Uncovering the mechanisms underlying cell cycle control in stem cells should thus provide insight into regulation of the balance between self-renewal and differentiation, a key goal of stem cell biology. Recent research has shown that cancer-initiating cells (CICs), a cell population with stem cell-like properties in cancer, are also quiescent, with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of the mechanisms of CIC quiescence might therefore be expected to provide a basis for the eradication of cancer. This review summarises our current understanding of the role of F-box and WD40 repeat domain-containing 7 (Fbxw7), a key regulator of the cell cycle, in the maintenance of normal stem cells and CICs, as well as attempts to define future challenges in this field. äRole of Fbxw7 in the maintenance of normal stem cells and cancer-initi(epmc).pdf DeepDyve Pubget Overpricing