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10.1038/bjc.2014.84 http://scihub22266oqcxt.onion/10.1038/bjc.2014.84 C4453743!4453743!25233399     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 2014 ; 111 (9): 1688-92 Nephropedia Template TP {{tp|p=25233399|t=2014. Novel functions of chromatin-bound I?B? in oncogenic transformation |pdf=|usr=}}{{25233399}} gab.com Text Novel functions of chromatin-bound I B in oncogenic transformation JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25233399 #FOAvip The nuclear factor-?B (NF-?B) signalling pathway participates in a multitude of biological processes, which imply the requirement of a complex and precise regulation. I?B (for Inhibitor of kappaB) proteins, which bind and retain NF-?B dimers in the cytoplasm, are the main contributors to negative regulation of NF-?B under non-stimulation conditions. Nevertheless, increasing evidences indicate that I?B proteins exert specific nuclear roles that directly contribute to the control of gene transcription. In particular, hypophosphorylated I?B? can bind the promoter region of TNF? leading to persistent gene transcription in macrophages and contributing to the regulation of the inflammatory response. Recently, we demonstrated that phosphorylated and SUMOylated I?B? reside in the nucleus of the cells where it binds to chromatin leading to specific transcriptional repression. Mechanistically, I?B? associates and regulates Polycomb Repressor Complex activity, a function that is evolutionary conserved from flies to mammals, as indicate the homeotic phenotype of Drosophila mutants. Here we discuss the implications of chromatin-bound I?B? function in the context of tumorigenesis. Twit Text FOAVip Novel functions of chromatin-bound I B in oncogenic transformation ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25233399 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25233399 #FOAvip English Wikipedia <ref>{{Cite pmid|25233399}}</ref> Novel functions of chromatin-bound I?B? in oncogenic transformation #MMPMID25233399 Espinosa L; Bigas A; Mulero MC Br J Cancer 2014[Oct]; 111 (9): 1688-92 PMID25233399show ga The nuclear factor-?B (NF-?B) signalling pathway participates in a multitude of biological processes, which imply the requirement of a complex and precise regulation. I?B (for Inhibitor of kappaB) proteins, which bind and retain NF-?B dimers in the cytoplasm, are the main contributors to negative regulation of NF-?B under non-stimulation conditions. Nevertheless, increasing evidences indicate that I?B proteins exert specific nuclear roles that directly contribute to the control of gene transcription. In particular, hypophosphorylated I?B? can bind the promoter region of TNF? leading to persistent gene transcription in macrophages and contributing to the regulation of the inflammatory response. Recently, we demonstrated that phosphorylated and SUMOylated I?B? reside in the nucleus of the cells where it binds to chromatin leading to specific transcriptional repression. Mechanistically, I?B? associates and regulates Polycomb Repressor Complex activity, a function that is evolutionary conserved from flies to mammals, as indicate the homeotic phenotype of Drosophila mutants. Here we discuss the implications of chromatin-bound I?B? function in the context of tumorigenesis. äNovel functions of chromatin-bound I?B? in oncogenic transformation (epmc).pdf DeepDyve Pubget Overpricing