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10.3389/fimmu.2015.00264 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00264 C4453475!4453475!26089820     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26089820|t=2015. Natural Killer Cell Immunotherapy: From Bench to Bedside |pdf=|usr=}}{{26089820}} gab.com Text Natural Killer Cell Immunotherapy: From Bench to Bedside JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26089820 #FOAvip The potential of natural killer (NK) cells to target numerous malignancies in vitro has been well documented; however, only limited success has been seen in the clinic. Although NK cells prove non-toxic and safe regardless of the cell numbers injected, there is often little persistence and expansion observed in a patient, which is vital for mounting an effective cellular response. NK cells can be isolated directly from peripheral blood, umbilical cord blood, or bone marrow, expanded in vitro using cytokines or differentiated in vitro from hematopoietic stem cells. Drugs that support NK cell function such as lenalidomide and bortezomib have also been studied in the clinic, however, the optimum combination, which can vary among different malignancies, is yet to be identified. NK cell proliferation, persistence, and function can further be improved by various activation techniques such as priming and cytokine addition though whether stimulation pre- or post-injection is more favorable is another obstacle to be tackled. Here, we review the various methods of obtaining and activating NK cells for use in the clinic while considering the ideal product and drug complement for the most successful cellular therapy. Twit Text FOAVip Natural Killer Cell Immunotherapy: From Bench to Bedside ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26089820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26089820 #FOAvip English Wikipedia <ref>{{Cite pmid|26089820}}</ref> Natural Killer Cell Immunotherapy: From Bench to Bedside #MMPMID26089820 Domogala A; Madrigal JA; Saudemont A Front Immunol 2015[]; 6 (ä): ä PMID26089820show ga The potential of natural killer (NK) cells to target numerous malignancies in vitro has been well documented; however, only limited success has been seen in the clinic. Although NK cells prove non-toxic and safe regardless of the cell numbers injected, there is often little persistence and expansion observed in a patient, which is vital for mounting an effective cellular response. NK cells can be isolated directly from peripheral blood, umbilical cord blood, or bone marrow, expanded in vitro using cytokines or differentiated in vitro from hematopoietic stem cells. Drugs that support NK cell function such as lenalidomide and bortezomib have also been studied in the clinic, however, the optimum combination, which can vary among different malignancies, is yet to be identified. NK cell proliferation, persistence, and function can further be improved by various activation techniques such as priming and cytokine addition though whether stimulation pre- or post-injection is more favorable is another obstacle to be tackled. Here, we review the various methods of obtaining and activating NK cells for use in the clinic while considering the ideal product and drug complement for the most successful cellular therapy. äNatural Killer Cell Immunotherapy: From Bench to Bedside (epmc).pdf DeepDyve Pubget Overpricing