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10.1038/bjc.2014.604 http://scihub22266oqcxt.onion/10.1038/bjc.2014.604 C4453458!4453458 !25461803     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25461803 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Cancer 2015 ; 112 (2 ): 382-90 Nephropedia Template TP {{tp|p=25461803 |t=2015. The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer |pdf=|usr=}}{{25461803 }} gab.com Text The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25461803 #FOAvip BACKGROUND: The hypoxia marker pimonidazole is a candidate biomarker of cancer aggressiveness. We investigated the transcriptional programme associated with pimonidazole staining in prostate cancer. METHODS: Index tumour biopsies were taken by image guidance from an investigation cohort of 52 patients, where 43 patients received pimonidazole before prostatectomy. Biopsy location within the index tumour was verified for 46 (88%) patients, who were included for gene expression profiling and immunohistochemistry. Two independent cohorts of 59 and 281 patients were used for validation. RESULTS: Expression of genes in proliferation, DNA repair and hypoxia response was a major part of the transcriptional programme associated with pimonidazole staining. A signature of 32 essential genes was constructed and showed positive correlation to Ki67 staining, confirming the increased proliferation in hypoxic tumours as suggested from the gene data. Positive correlations were also found to tumour stage and lymph node status, but not to blood prostate-specific antigen level, consistent with the findings for pimonidazole staining. The association with aggressiveness was confirmed in validation cohorts, where the signature correlated with Gleason score and had independent prognostic impact, respectively. CONCLUSIONS: Pimonidazole staining reflects an aggressive hypoxic phenotype of prostate cancer characterised by upregulation of proliferation, DNA repair and hypoxia response genes. Twit Text FOAVip The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25461803 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25461803 #FOAvip English Wikipedia <ref>{{Cite pmid|25461803 }}</ref> The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer #MMPMID25461803 Ragnum HB ; Vlatkovic L ; Lie AK ; Axcrona K ; Julin CH ; Frikstad KM ; Hole KH ; Seierstad T ; Lyng H Br J Cancer 2015[Jan]; 112 (2 ): 382-90 PMID25461803 show ga BACKGROUND: The hypoxia marker pimonidazole is a candidate biomarker of cancer aggressiveness. We investigated the transcriptional programme associated with pimonidazole staining in prostate cancer. METHODS: Index tumour biopsies were taken by image guidance from an investigation cohort of 52 patients, where 43 patients received pimonidazole before prostatectomy. Biopsy location within the index tumour was verified for 46 (88%) patients, who were included for gene expression profiling and immunohistochemistry. Two independent cohorts of 59 and 281 patients were used for validation. RESULTS: Expression of genes in proliferation, DNA repair and hypoxia response was a major part of the transcriptional programme associated with pimonidazole staining. A signature of 32 essential genes was constructed and showed positive correlation to Ki67 staining, confirming the increased proliferation in hypoxic tumours as suggested from the gene data. Positive correlations were also found to tumour stage and lymph node status, but not to blood prostate-specific antigen level, consistent with the findings for pimonidazole staining. The association with aggressiveness was confirmed in validation cohorts, where the signature correlated with Gleason score and had independent prognostic impact, respectively. CONCLUSIONS: Pimonidazole staining reflects an aggressive hypoxic phenotype of prostate cancer characterised by upregulation of proliferation, DNA repair and hypoxia response genes. |*Nitroimidazoles/pharmacokinetics [MESH] |*Transcriptome [MESH] |Cell Hypoxia [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Lymphatic Metastasis [MESH] |Male [MESH] |Proportional Hazards Models [MESH] |Prostatic Neoplasms/metabolism/mortality/*pathology [MESH] |Staining and Labeling [MESH]The tumour hypoxia marker pimonidazole reflects a transcriptional prog(epmc).pdf DeepDyve Pubget Overpricing