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10.1038/srep10564 http://scihub22266oqcxt.onion/10.1038/srep10564 C4453164!4453164 !26037491     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26037491 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 10564 Nephropedia Template TP {{tp|p=26037491 |t=2015. A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly |pdf=|usr=}}{{26037491 }} gab.com Text A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26037491 #FOAvip How multiple spindle assembly pathways are integrated to drive bipolar spindle assembly is poorly understood. We performed an image-based double RNAi screen to identify genes encoding Microtubule-Associated Proteins (MAPs) that interact with the highly conserved ch-TOG gene to regulate bipolar spindle assembly in human cells. We identified a ch-TOG centred network of genetic interactions which promotes centrosome-mediated microtubule polymerisation, leading to the incorporation of microtubules polymerised by all pathways into a bipolar structure [corrected]. Our genetic screen also reveals that ch-TOG maintains a dynamic microtubule population, in part, through modulating HSET activity. ch-TOG ensures that spindle assembly is robust to perturbation but sufficiently dynamic such that spindles can explore a diverse shape space in search of structures that can align chromosomes. Twit Text FOAVip A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26037491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26037491 #FOAvip English Wikipedia <ref>{{Cite pmid|26037491 }}</ref> A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly #MMPMID26037491 Barr AR ; Bakal C Sci Rep 2015[Jun]; 5 (ä): 10564 PMID26037491 show ga How multiple spindle assembly pathways are integrated to drive bipolar spindle assembly is poorly understood. We performed an image-based double RNAi screen to identify genes encoding Microtubule-Associated Proteins (MAPs) that interact with the highly conserved ch-TOG gene to regulate bipolar spindle assembly in human cells. We identified a ch-TOG centred network of genetic interactions which promotes centrosome-mediated microtubule polymerisation, leading to the incorporation of microtubules polymerised by all pathways into a bipolar structure [corrected]. Our genetic screen also reveals that ch-TOG maintains a dynamic microtubule population, in part, through modulating HSET activity. ch-TOG ensures that spindle assembly is robust to perturbation but sufficiently dynamic such that spindles can explore a diverse shape space in search of structures that can align chromosomes. |*Epistasis, Genetic [MESH] |*Gene Regulatory Networks [MESH] |*RNA Interference [MESH] |Chromatin/metabolism [MESH] |Cluster Analysis [MESH] |Dyneins/metabolism [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Kinesins/genetics/metabolism [MESH] |Microtubule-Associated Proteins/*genetics/*metabolism [MESH] |Microtubules/metabolism [MESH] |Mitosis [MESH] |Protein Binding [MESH] |RNA, Small Interfering/genetics [MESH] |Spindle Apparatus/*metabolism [MESH]A sensitised RNAi screen reveals a ch-TOG genetic interaction network (epmc).pdf DeepDyve Pubget Overpricing