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10.3389/fmicb.2015.00546

http://scihub22266oqcxt.onion/10.3389/fmicb.2015.00546
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C4452884!4452884!26089819
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suck abstract from ncbi


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pmid26089819      Front+Microbiol 2015 ; 6 (ä): ä
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  • Automatic day-2 intervention by a multidisciplinary antimicrobial stewardship-team leads to multiple positive effects #MMPMID26089819
  • Dik JWH; Hendrix R; Lo-Ten-Foe JR; Wilting KR; Panday PN; van Gemert-Pijnen LE; Leliveld AM; van der Palen J; Friedrich AW; Sinha B
  • Front Microbiol 2015[]; 6 (ä): ä PMID26089819show ga
  • Background: Antimicrobial resistance rates are increasing. This is, among others, caused by incorrect or inappropriate use of antimicrobials. To target this, a multidisciplinary antimicrobial stewardship-team (A-Team) was implemented at the University Medical Center Groningen on a urology ward. Goal of this study is to evaluate the clinical effects of the case-audits done by this team, looking at length of stay (LOS) and antimicrobial use.Methods: Automatic e-mail alerts were sent after 48 h of consecutive antimicrobial use triggering the case-audits, consisting of an A-Team member visiting the ward, discussing the patient?s therapy with the bed-side physician and together deciding on further treatment based on available diagnostics and guidelines. Clinical effects of the audits were evaluated through an Interrupted Time Series analysis and a retrospective historic cohort.Results: A significant systemic reduction of antimicrobial consumption for all patients on the ward, both with and without case-audits was observed. Furthermore, LOS for patients with case-audits who were admitted primarily due to infections decreased to 6.20 days (95% CI: 5.59?6.81) compared to the historic cohort (7.57 days; 95% CI: 6.92?8.21; p = 0.012). Antimicrobial consumption decreased for these patients from 8.17 DDD/patient (95% CI: 7.10?9.24) to 5.93 DDD/patient (95% CI: 5.02?6.83; p = 0.008). For patients with severe underlying diseases (e.g., cancer) these outcome measures remained unchanged.Conclusion: The evaluation showed a considerable positive impact. Antibiotic use of the whole ward was reduced, transcending the intervened patients. Furthermore, LOS and mean antimicrobial consumption for a subgroup was reduced, thereby improving patient care and potentially lowering resistance rates.
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