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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Gastroenterol+Res+Pract
2015 ; 2015
(ä): 796461
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IFN-?: A New Class of Interferon with Distinct Functions-Implications for
Hepatitis C Virus Research
#MMPMID26078754
Liu B
; McGilvray I
; Chen L
Gastroenterol Res Pract
2015[]; 2015
(ä): 796461
PMID26078754
show ga
Pegylated interferon-? and ribavirin (PEG-IFN/RBV) is widely used to treat
chronic hepatitis C virus infection with notorious adverse reactions since the
broad expression of IFN-? receptors on all nucleated cells. Accordingly, a Type
III IFN with restricted receptors distribution is much safer as an alternative
for HCV therapy. In addition, single nucleotide polymorphisms (SNPs) near the
human IFN-?3 gene, IL-28B, correlate strongly with the ability to achieve a
sustained virological response (SVR) to therapy with pegylated IFN-? plus
ribavirin in patients infected with chronic hepatitis C. Furthermore, we also
discuss the most recent findings: IFN-?4 predicts treatment outcomes of HCV
infection. In consideration of the apparent limitations of current HCV therapy,
especially high failure rate and universal side effects, prediction of treatment
outcomes prior to the initiation of treatment and developing new alternative
drugs are two important goals in HCV research.