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10.1158/0008-5472.CAN-14-2493 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2493 C4452392!4452392 !25855383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25855383 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases |pdf=|usr=}}{{25855383 }} gab.com Text Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25855383 #FOAvip Cross-talk between tumor cells and their microenvironment is critical for malignant progression. Cross-talk mediators, including soluble factors and direct cell contact, have been identified, but roles for the interaction of physical forces between tumor cells and the bone microenvironment have not been described. Here, we report preclinical evidence that tumor-generated pressure acts to modify the bone microenvironment to promote the growth of prostate cancer bone metastases. Tumors growing in mouse tibiae increased intraosseous pressure. Application of pressure to osteocytes, the main mechanotransducing cells in bone, induced prostate cancer growth and invasion. Mechanistic investigations revealed that this process was mediated in part by upregulation of CCL5 and matrix metalloproteinases in osteocytes. Our results defined the critical contribution of physical forces to tumor cell growth in the tumor microenvironment, and they identified osteocytes as a critical mediator in the bone metastatic niche. Twit Text FOAVip Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25855383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25855383 #FOAvip English Wikipedia <ref>{{Cite pmid|25855383 }}</ref> Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases #MMPMID25855383 Sottnik JL ; Dai J ; Zhang H ; Campbell B ; Keller ET Cancer Res 2015[Jun]; 75 (11 ): 2151-8 PMID25855383 show ga Cross-talk between tumor cells and their microenvironment is critical for malignant progression. Cross-talk mediators, including soluble factors and direct cell contact, have been identified, but roles for the interaction of physical forces between tumor cells and the bone microenvironment have not been described. Here, we report preclinical evidence that tumor-generated pressure acts to modify the bone microenvironment to promote the growth of prostate cancer bone metastases. Tumors growing in mouse tibiae increased intraosseous pressure. Application of pressure to osteocytes, the main mechanotransducing cells in bone, induced prostate cancer growth and invasion. Mechanistic investigations revealed that this process was mediated in part by upregulation of CCL5 and matrix metalloproteinases in osteocytes. Our results defined the critical contribution of physical forces to tumor cell growth in the tumor microenvironment, and they identified osteocytes as a critical mediator in the bone metastatic niche. |*Pressure [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Bone Neoplasms/*pathology/secondary [MESH] |Cell Proliferation/physiology [MESH] |Chemokine CCL5/biosynthesis [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Male [MESH] |Matrix Metalloproteinases/biosynthesis [MESH] |Mice [MESH] |Neoplasm Metastasis [MESH] |Osteocytes/metabolism/pathology [MESH]Tumor-induced pressure in the bone microenvironment causes osteocytes (epmc).pdf DeepDyve Pubget Overpricing