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2015 ; 2015
(ä): 519638
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Increased Serum Interleukin-9 Levels in Rheumatoid Arthritis and Systemic Lupus
Erythematosus: Pathogenic Role or Just an Epiphenomenon?
#MMPMID26078482
Dantas AT
; Marques CD
; da Rocha Junior LF
; Cavalcanti MB
; Gonçalves SM
; Cardoso PR
; Mariz Hde A
; Rego MJ
; Duarte AL
; Pitta Ida R
; Pitta MG
Dis Markers
2015[]; 2015
(ä): 519638
PMID26078482
show ga
The purpose of this paper was to evaluate the levels of IL-9 in patients with SLE
and RA compared with controls and the association of IL-9 levels with clinical
and laboratory parameters. IL-9 levels were assessed in 117 SLE patients, 67 RA
patients, and 24 healthy controls by ELISA. Clinical and laboratory parameters
were recorded. The IL-9 serum levels were significantly higher in RA patients
(4,77 ± 3,618 pg/mL) and in SLE patients (12,26 ± 25,235 pg/mL) than in healthy
individuals (1,22 ± 0,706 pg/mL) (p < 0,001). In SLE patients, there were no
statistically significant associations or correlations between the levels of IL-9
and SLEDAI or other clinical and laboratorial parameters, with the exception of
disease time, which showed a statistically significant negative correlation with
IL-9 levels (r = -0,1948; p = 0,0378). In RA patients, no association or
statistically significant correlation was observed with disease duration, DAS28,
HAQ, rheumatoid factor positivity, or erosions on radiography. These data
demonstrated increased serum levels of IL-9 in SLE and RA patients, but further
studies are needed to clarify the precise role of this cytokine and its potential
use as therapeutic target.