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10.1155/2015/519638

http://scihub22266oqcxt.onion/10.1155/2015/519638
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suck abstract from ncbi


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pmid26078482
      Dis+Markers 2015 ; 2015 (ä): 519638
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  • Increased Serum Interleukin-9 Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Pathogenic Role or Just an Epiphenomenon? #MMPMID26078482
  • Dantas AT ; Marques CD ; da Rocha Junior LF ; Cavalcanti MB ; Gonçalves SM ; Cardoso PR ; Mariz Hde A ; Rego MJ ; Duarte AL ; Pitta Ida R ; Pitta MG
  • Dis Markers 2015[]; 2015 (ä): 519638 PMID26078482 show ga
  • The purpose of this paper was to evaluate the levels of IL-9 in patients with SLE and RA compared with controls and the association of IL-9 levels with clinical and laboratory parameters. IL-9 levels were assessed in 117 SLE patients, 67 RA patients, and 24 healthy controls by ELISA. Clinical and laboratory parameters were recorded. The IL-9 serum levels were significantly higher in RA patients (4,77 ± 3,618 pg/mL) and in SLE patients (12,26 ± 25,235 pg/mL) than in healthy individuals (1,22 ± 0,706 pg/mL) (p < 0,001). In SLE patients, there were no statistically significant associations or correlations between the levels of IL-9 and SLEDAI or other clinical and laboratorial parameters, with the exception of disease time, which showed a statistically significant negative correlation with IL-9 levels (r = -0,1948; p = 0,0378). In RA patients, no association or statistically significant correlation was observed with disease duration, DAS28, HAQ, rheumatoid factor positivity, or erosions on radiography. These data demonstrated increased serum levels of IL-9 in SLE and RA patients, but further studies are needed to clarify the precise role of this cytokine and its potential use as therapeutic target.
  • |Adult [MESH]
  • |Aged [MESH]
  • |Arthritis, Rheumatoid/blood/*metabolism [MESH]
  • |Biomarkers/blood [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Interleukin-9/*blood [MESH]
  • |Lupus Erythematosus, Systemic/blood/*metabolism [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Up-Regulation [MESH]


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