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10.1155/2015/151626 http://scihub22266oqcxt.onion/10.1155/2015/151626 C4452340!4452340 !26090479     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26090479 &cmd=llinks): Failed to open stream: HTTP request failed! 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Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis |pdf=|usr=}}{{26090479 }} gab.com Text Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26090479 #FOAvip OBJECTIVE: To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). METHODS: In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified. RESULTS: Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P < 0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P = 0.003) and + RF (P = 0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P = 0.02) and with fibrosis score DD (P = 0.01), anti-CCP2 titers (P < 0.001), and MTX treatment duration (P < 0.001). CONCLUSIONS: Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD. Twit Text FOAVip Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26090479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26090479 #FOAvip English Wikipedia <ref>{{Cite pmid|26090479 }}</ref> Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstitial Lung Disease in Women with Rheumatoid Arthritis #MMPMID26090479 Rocha-Muñoz AD ; Ponce-Guarneros M ; Gamez-Nava JI ; Olivas-Flores EM ; Mejía M ; Juárez-Contreras P ; Martínez-García EA ; Corona-Sánchez EG ; Rodríguez-Hernández TM ; Vázquez-del Mercado M ; Salazar-Páramo M ; Nava-Zavala AH ; Cardona-Muñoz EG ; Celis A ; González-Lopez L J Immunol Res 2015[]; 2015 (ä): 151626 PMID26090479 show ga OBJECTIVE: To evaluate whether serum titers of second-generation anticyclic citrullinated peptide antibodies (anti-CCP2) are associated with the severity and extent of interstitial lung disease in rheumatoid arthritis (RA-ILD). METHODS: In across-sectional study, 39 RA-ILD patients confirmed by high-resolution computed tomography (HRCT) were compared with 42 RA without lung involvement (RA only). Characteristics related to RA-ILD were assessed in all of the patients and serum anti-CCP2 titers quantified. RESULTS: Higher anti-CCP2 titers were found in RA-ILD compared with RA only (medians 77.9 versus 30.2 U/mL, P < 0.001). In the logistic regression analysis after adjustment for age, disease duration (DD), smoke exposure, disease activity, functioning, erythrocyte sedimentation rate, and methotrexate (MTX) treatment duration, the characteristics associated with RA-ILD were higher anti-CCP2 titers (P = 0.003) and + RF (P = 0.002). In multivariate linear regression, the variables associated with severity of ground-glass score were anti-CCP2 titers (P = 0.02) and with fibrosis score DD (P = 0.01), anti-CCP2 titers (P < 0.001), and MTX treatment duration (P < 0.001). CONCLUSIONS: Anti-CCP2 antibodies are markers of severity and extent of RA-ILD in HRCT. Further longitudinal studies are required to identify if higher anti-CCP2 titers are associated with worst prognosis in RA-ILD. |Adult [MESH] |Aged [MESH] |Antibodies/*immunology [MESH] |Antirheumatic Agents/therapeutic use [MESH] |Arthritis, Rheumatoid/blood/drug therapy/*immunology/*pathology [MESH] |Biomarkers/blood [MESH] |Cross-Sectional Studies [MESH] |Erythrocytes/immunology/pathology [MESH] |Female [MESH] |Fibrosis/drug therapy/immunology/pathology [MESH] |Humans [MESH] |Lung Diseases, Interstitial/blood/*immunology/*pathology [MESH] |Methotrexate/therapeutic use [MESH] |Middle Aged [MESH] |Peptides, Cyclic/*immunology [MESH] |Severity of Illness Index [MESH]Anti-Cyclic Citrullinated Peptide Antibodies and Severity of Interstit(epmc).pdf DeepDyve Pubget Overpricing