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Clinical Characteristics of Cerebral Venous Sinus Thrombosis in Patients with
Systemic Lupus Erythematosus: A Single-Centre Experience in China
#MMPMID26090493
Wang L
; Chen H
; Zhang Y
; Liu W
; Zheng W
; Zhang X
; Zhang F
J Immunol Res
2015[]; 2015
(?): 540738
PMID26090493
show ga
Clinical characteristics of systemic lupus erythematosus (SLE) patients
complicated with cerebral venous sinus thrombosis (CVST) between 2000 and 2013
were analyzed through this retrospective, single-centre study. Of 4747
hospitalized SLE patients, 17 (0.36%, 12 females, average age 30) had CVST.
Headache (88.2%) was the most common neurological symptom followed by nausea or
vomiting (47.1%), conscious disturbance (41.2%), edema of eyelids or conjunctiva
(35.3%), blurred vision or diplopia (35.3%), and seizure (35.3%). Increased
intracranial pressure (ICP) occurred in 13 cases (76.5%). Magnetic resonance
venography (MRV) detected thrombosis in the transverse (82.4%), sigmoid (52.9%),
and sagittal (35.3%) sinuses, with frequent (70.6%) multiple sinus occlusions.
Compared to SLE patients without CVST, SLE patients with CVST had a higher
prevalence of thrombocytopenia and positive antiphospholipid antibodies and a
higher SLE disease activity index (SLEDAI) score. 13 patients achieved
improvement following glucocorticoids and immunosuppressants treatment, as well
as anticoagulants, while 3 patients died at the hospital. CVST is relatively rare
in SLE and tends to occur in active lupus patients. Intracranial hypertension is
common but nonspecific clinical feature, so MRV evaluation is necessary to
establish a diagnosis. Aggressive treatment for the rapid control of SLE activity
combined with anticoagulants can improve the prognosis.
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