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2015 ; 2015
(ä): 964849
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Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium
following Acute Kidney Injury
#MMPMID26089922
Maeshima A
; Takahashi S
; Nakasatomi M
; Nojima Y
Stem Cells Int
2015[]; 2015
(ä): 964849
PMID26089922
show ga
Renal tubular epithelium has the capacity to regenerate, repair, and
reepithelialize in response to a variety of insults. Previous studies with
several kidney injury models demonstrated that various growth factors,
transcription factors, and extracellular matrices are involved in this process.
Surviving tubular cells actively proliferate, migrate, and differentiate in the
kidney regeneration process after injury, and some cells express putative stem
cell markers or possess stem cell properties. Using fate mapping techniques, bone
marrow-derived cells and endothelial progenitor cells have been shown to
transdifferentiate into tubular components in vivo or ex vivo. Similarly, it has
been demonstrated that, during tubular cell regeneration, several inflammatory
cell populations migrate, assemble around tubular cells, and interact with
tubular cells during the repair of tubular epithelium. In this review, we
describe recent advances in understanding the regeneration mechanisms of renal
tubules, particularly the characteristics of various cell populations
contributing to tubular regeneration, and highlight the targets for the
development of regenerative medicine for treating kidney diseases in humans.