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10.1111/cas.12638 http://scihub22266oqcxt.onion/10.1111/cas.12638 C4452160!4452160 !25702890     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25702890 &cmd=llinks): Failed to open stream: HTTP request failed! 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High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma |pdf=|usr=}}{{25702890 }} gab.com Text High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25702890 #FOAvip Interleukin-11 (IL-11), a member of the IL-6 family of cytokines, exerts pleiotropic oncogenic activities by stimulating angiogenesis and metastasis in many cancer types. The present study aims to evaluate the impact of IL-11 expression on recurrence and mortality of patients with clear-cell renal cell carcinoma (ccRCC). We retrospectively enrolled 193 ccRCC patients undergoing nephrectomy at a single center. Clinicopathologic features, recurrence-free survival (RFS) and overall survival (OS) were recorded. IL-11 intensity was assessed by immunohistochemistry in tumor specimens. The Kaplan-Meier method was applied to compare survival curves. Cox regression models were used to analyze the impact of prognostic factors on RFS and OS. The concordance index (C-index) was calculated to assess predictive accuracy. High IL-11 expression is associated with increased risk of recurrence and poor survival for ccRCC patients (P < 0.001 and P < 0.001, respectively), especially those with early-stage disease (TNM stage I + II). Multivariate analyses confirmed that IL-11 expression was an independent prognostic factor for RFS and OS (P = 0.006 and P = 0.008, respectively). The predictive accuracy of well-established prognostic models was improved when IL-11 expression was integrated. In conclusion, high IL-11 expression is an independent predictor of poor prognosis in ccRCC patients. It may help identify patients who could benefit from additional treatments and closer follow up. Twit Text FOAVip High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25702890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25702890 #FOAvip English Wikipedia <ref>{{Cite pmid|25702890 }}</ref> High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma #MMPMID25702890 Pan D ; Xu L ; Liu H ; Zhang W ; Liu W ; Liu Y ; Fu Q ; Xu J Cancer Sci 2015[May]; 106 (5 ): 592-7 PMID25702890 show ga Interleukin-11 (IL-11), a member of the IL-6 family of cytokines, exerts pleiotropic oncogenic activities by stimulating angiogenesis and metastasis in many cancer types. The present study aims to evaluate the impact of IL-11 expression on recurrence and mortality of patients with clear-cell renal cell carcinoma (ccRCC). We retrospectively enrolled 193 ccRCC patients undergoing nephrectomy at a single center. Clinicopathologic features, recurrence-free survival (RFS) and overall survival (OS) were recorded. IL-11 intensity was assessed by immunohistochemistry in tumor specimens. The Kaplan-Meier method was applied to compare survival curves. Cox regression models were used to analyze the impact of prognostic factors on RFS and OS. The concordance index (C-index) was calculated to assess predictive accuracy. High IL-11 expression is associated with increased risk of recurrence and poor survival for ccRCC patients (P < 0.001 and P < 0.001, respectively), especially those with early-stage disease (TNM stage I + II). Multivariate analyses confirmed that IL-11 expression was an independent prognostic factor for RFS and OS (P = 0.006 and P = 0.008, respectively). The predictive accuracy of well-established prognostic models was improved when IL-11 expression was integrated. In conclusion, high IL-11 expression is an independent predictor of poor prognosis in ccRCC patients. It may help identify patients who could benefit from additional treatments and closer follow up. |Biomarkers, Tumor/*analysis [MESH] |Carcinoma, Renal Cell/*metabolism/*mortality/pathology/surgery [MESH] |Cohort Studies [MESH] |Female [MESH] |Humans [MESH] |Interleukin-11/*analysis [MESH] |Kaplan-Meier Estimate [MESH] |Kidney Neoplasms/*metabolism/*mortality/pathology/surgery [MESH] |Male [MESH] |Middle Aged [MESH] |Neoplasm Recurrence, Local [MESH] |Nephrectomy [MESH] |Prognosis [MESH] |Proportional Hazards Models [MESH]High expression of interleukin-11 is an independent indicator of poor (epmc).pdf DeepDyve Pubget Overpricing