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10.1016/j.blre.2014.10.003 http://scihub22266oqcxt.onion/10.1016/j.blre.2014.10.003 C4452143!4452143!25468720     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Rev 2015 ; 29 (3): 153-62 Nephropedia Template TP {{tp|p=25468720|t=2015. Platelet secretion: From haemostasis to wound healing and beyond |pdf=|usr=}}{{25468720}} gab.com Text Platelet secretion: From haemostasis to wound healing and beyond JO: Blood Rev http://www.kidney.de/pget.php?&tw=1&pmid=25468720 #FOAvip Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. ?-Granules contain multiple cytokines, mitogens, pro- and anti-inflammatory factors and other bioactive molecules that are essential regulators in the complex microenvironment of the growing thrombus but also contribute to a number of disease processes. Our understanding of the molecular mechanisms of secretion and the genetic regulation of granule biogenesis still remains incomplete. In this review we summarise our current understanding of the roles of platelet secretion in health and disease, and discuss some of the hypotheses that may explain how platelets may control the release of its many secreted components in a context-specific manner, to allow platelets to play multiple roles in health and disease. Twit Text FOAVip Platelet secretion: From haemostasis to wound healing and beyond ????Blood Rev http://www.kidney.de/pget.php?&tw=1&pmid=25468720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468720 #FOAvip English Wikipedia <ref>{{Cite pmid|25468720}}</ref> Platelet secretion: From haemostasis to wound healing and beyond #MMPMID25468720 Golebiewska EM; Poole AW Blood Rev 2015[May]; 29 (3): 153-62 PMID25468720show ga Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. ?-Granules contain multiple cytokines, mitogens, pro- and anti-inflammatory factors and other bioactive molecules that are essential regulators in the complex microenvironment of the growing thrombus but also contribute to a number of disease processes. Our understanding of the molecular mechanisms of secretion and the genetic regulation of granule biogenesis still remains incomplete. In this review we summarise our current understanding of the roles of platelet secretion in health and disease, and discuss some of the hypotheses that may explain how platelets may control the release of its many secreted components in a context-specific manner, to allow platelets to play multiple roles in health and disease. äPlatelet secretion: From haemostasis to wound healing and beyond (epmc).pdf DeepDyve Pubget Overpricing