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10.1155/2015/832916 http://scihub22266oqcxt.onion/10.1155/2015/832916 C4452103!4452103 !26090500     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26090500 &cmd=llinks): Failed to open stream: HTTP request failed! 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Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus |pdf=|usr=}}{{26090500 }} gab.com Text Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26090500 #FOAvip PURPOSES: To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS: The B cell subsets and LRs expression were determined by flow cytometry and confocal microscopy, and F-actin expression was examined by confocal microscopy. RESULTS: CD27(+)IgD(+) B cell subsets were significantly decreased while CD38(+)CD95(+) B cell subsets increased in SLE patients. The LRs levels of B cells were remarkably increased and positively correlated with SLEDAI and anti-dsDNA titer in SLE patients. The expression level of LRs was significantly higher in CD38(+) B cells than CD38(-) B cells and negatively correlated with C3 levels. The increased expression of LRs was associated with reduced expression of F-actin in the B cells from active SLE patients. Furthermore, in vitro treatment of the cells with A771726 reduced the expression level of LRs, attenuated the overaggregation of LRs, and normalized the distribution of F-actin. CONCLUSIONS: There were abnormalities in B cell subsets and LRs and F-actin expression of B cell from SLE patients. Modulation of B cell expression of LRs and F-actin by LEF could be a potential therapeutic target for SLE. Twit Text FOAVip Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26090500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26090500 #FOAvip English Wikipedia <ref>{{Cite pmid|26090500 }}</ref> Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-Actin in B Lymphocytes from Patients with Systemic Lupus Erythematosus #MMPMID26090500 Dong GF ; Zhang X ; He DN ; Li L ; Zhang GF J Immunol Res 2015[]; 2015 (ä): 832916 PMID26090500 show ga PURPOSES: To investigate the possible changes in B cell subsets and in B cell expression patterns of lipid rafts (LRs) and F-actin in patients with SLE and whether leflunomide treatment may have effect on these changes. METHODS: The B cell subsets and LRs expression were determined by flow cytometry and confocal microscopy, and F-actin expression was examined by confocal microscopy. RESULTS: CD27(+)IgD(+) B cell subsets were significantly decreased while CD38(+)CD95(+) B cell subsets increased in SLE patients. The LRs levels of B cells were remarkably increased and positively correlated with SLEDAI and anti-dsDNA titer in SLE patients. The expression level of LRs was significantly higher in CD38(+) B cells than CD38(-) B cells and negatively correlated with C3 levels. The increased expression of LRs was associated with reduced expression of F-actin in the B cells from active SLE patients. Furthermore, in vitro treatment of the cells with A771726 reduced the expression level of LRs, attenuated the overaggregation of LRs, and normalized the distribution of F-actin. CONCLUSIONS: There were abnormalities in B cell subsets and LRs and F-actin expression of B cell from SLE patients. Modulation of B cell expression of LRs and F-actin by LEF could be a potential therapeutic target for SLE. |Actins/*immunology [MESH] |Adult [MESH] |Aniline Compounds/therapeutic use [MESH] |Antigens, CD/immunology [MESH] |B-Lymphocytes/*drug effects/*immunology [MESH] |Case-Control Studies [MESH] |Crotonates [MESH] |Female [MESH] |Humans [MESH] |Hydroxybutyrates/therapeutic use [MESH] |Immunoglobulin D/immunology [MESH] |Immunosuppressive Agents/*therapeutic use [MESH] |Isoxazoles/*therapeutic use [MESH] |Leflunomide [MESH] |Lupus Erythematosus, Systemic/immunology [MESH] |Male [MESH] |Membrane Microdomains/*drug effects/*immunology [MESH] |Nitriles [MESH]Effect of Leflunomide on the Abnormal Expression of Lipid Rafts and F-(epmc).pdf DeepDyve Pubget Overpricing