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2015 ; 2015
(ä): 713728
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Clinical Characteristics of Concomitant Systemic Lupus Erythematosus and Primary
Biliary Cirrhosis: A Literature Review
#MMPMID26090497
Shizuma T
J Immunol Res
2015[]; 2015
(ä): 713728
PMID26090497
show ga
Although autoimmune diseases often coexist, concomitant cases of systemic lupus
erythematosus (SLE) and primary biliary cirrhosis (PBC) are uncommon. In this
review paper, 34 cases of SLE with concomitant PBC found in English and Japanese
scientific literature and Japanese proceedings were reviewed and summarized,
including cases with liver dysfunction complicated by SLE. Of the 34 reported
concomitant cases of SLE and PBC, 97.1% (33/34) were females, and PBC was
diagnosed initially in 69.0% (20/29), except for five cases in which both SLE and
PBC were simultaneously diagnosed. Sjögren's syndrome was the most common
autoimmune disease complicating concomitant SLE and PBC (23.5%, 8/34). Five
deaths have been reported: two elderly patients died of liver failure because of
the worsening of PBC, and another two patients died from pulmonary infection
associated with SLE pharmacotherapy. It is uncertain whether concomitant cases
occur by chance or share a common immunological or genetic basis.