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10.1038/srep10665

http://scihub22266oqcxt.onion/10.1038/srep10665
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C4451845!4451845!26035423
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suck abstract from ncbi


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pmid26035423      Sci+Rep 2015 ; 5 (ä): ä
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  • Tumor-specific Th2 responses inhibit growth of CT26 colon-cancer cells in mice via converting intratumor regulatory T cells to Th9 cells #MMPMID26035423
  • Liu JQ; Li XY; Yu HQ; Yang G; Liu ZQ; Geng XR; Wang S; Mo LH; Zeng L; Zhao M; Fu YT; Sun HZ; Liu ZG; Yang PC
  • Sci Rep 2015[]; 5 (ä): ä PMID26035423show ga
  • The abnormality of immune regulation plays a critical role in the pathogenesis of cancer; the underlying mechanism has not been fully understood yet. This study aims to investigate the role of cancer specific T helper (Th)2 response in the inhibition of colon cancer (Cca) cell growth. The results showed that with Cca cell (CT26 cell) extracts as an antigen, the Cca-extract specific Th2 response was induced in the Cca-bearing mice. The Cca mass size was significantly reduced, or radically disappeared (5 out of 10; or 50%); the survival rate was markedly improved in mice immunized with Cca-extract, but not in those immunized with another tumor cell (U87 cell) extracts or to bovine serum albumin. The immunization with Cca-extract also induced Cca cell apoptosis and converted the intra-Cca Tregs to T helper (Th) 9 cells. In conclusion, Cca-specific Th2 responses inhibit Cca growth in a mouse model via inducing Cca cell apoptosis and converting intra-Cca Tregs to Th9 cells.
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