Interference with the Autophagic Process as a Viral Strategy to Escape from the
Immune Control: Lesson from Gamma Herpesviruses
#MMPMID26090494
Santarelli R
; Granato M
; Faggioni A
; Cirone M
J Immunol Res
2015[]; 2015
(?): 546063
PMID26090494
show ga
We summarized the most recent findings on the role of autophagy in antiviral
immune response. We described how viruses have developed strategies to subvert
the autophagic process. A particular attention has been given to Epstein-Barr and
Kaposi's sarcoma associated Herpesvirus, viruses studied for many years in our
laboratory. These two viruses belong to ?-Herpesvirus subfamily and are
associated with several human cancers. Besides the effects on the immune
response, we have described how autophagy subversion by viruses may also concur
to the enhancement of their replication and to viral tumorigenesis.