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10.5812/hepatmon.15(5)2015.27181

http://scihub22266oqcxt.onion/10.5812/hepatmon.15(5)2015.27181
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suck abstract from ncbi


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pmid26045707      Hepat+Mon 2015 ; 15 (5): ä
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  • A Comprehensive Long-Term Prognosis of Chronic Hepatitis C Patients With Antiviral Therapy: A Meta-Analysis of Studies From 2008 to 2014 #MMPMID26045707
  • Wen Y; Zheng YX; Tan DM
  • Hepat Mon 2015[May]; 15 (5): ä PMID26045707show ga
  • Context:: Attaining a sustained virological response with antiviral therapy is a sign of clinical cure for chronic hepatitis C patients. The aim of this meta-analysis was to evaluate the long-term efficiency and outcome of antiviral therapy in patients with hepatitis C who attained a sustained virological response. Evidence Acquisition:: A literature search was performed on published articles between January 2008 and February 2014. Patients with Hepatitis C who received interferon with or without ribavirin therapy were enrolled. Relative risks were estimated using either fixed or random effect models. Results:: Patients who attained sustained virological response had a less risk (85%) for all-cause mortality and about 63% reduced risk of hepatocellular carcinoma incidence than those who did not achieve sustained virological response. Based on deeply analysis, the stage of liver fibrosis was a risk factor at baseline for the incidence of hepatocellular carcinoma. Conclusions:: Sustained virological response can reduce all-cause mortality and the incidence of hepatocellular carcinoma of patients with hepatitis C. Advanced liver fibrosis is still a risk factor for the incidence of hepatocellular carcinoma, in spite of hepatitis C patients attained a sustained virological response.
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