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10.5812/hepatmon.15(5)2015.27336 http://scihub22266oqcxt.onion/10.5812/hepatmon.15(5)2015.27336 C4451276!4451276!26045708     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hepat+Mon 2015 ; 15 (5): ä Nephropedia Template TP {{tp|p=26045708|t=2015. Molecular Mechanisms for Alcoholic Hepatitis Based on Analysis of Gene Expression Profile |pdf=|usr=}}{{26045708}} gab.com Text Molecular Mechanisms for Alcoholic Hepatitis Based on Analysis of Gene Expression Profile JO: Hepat Mon http://www.kidney.de/pget.php?&tw=1&pmid=26045708 #FOAvip Background:: Alcoholic hepatitis (AH) is an acute manifestation of alcoholic liver disease with high mortality rates. Objectives:: Our aim was to study the molecular mechanisms of AH. Materials and Methods:: The differentially expressed genes (DEGs) in liver between AH and control cases were identified by analyzing the GSE28619 microarray data using t-test. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) enrichment analyses were performed using DAVID online tool. The protein-protein interaction (PPI) network was constructed using Search Tool for the Retrieval of Interacting Genes (STRING) and the subnetwork was identified by BioNet. Both PPI network and subnetwork were visualized using the Cytoscape software. Results:: Total 908 DEGs (551 up- and 357 down-regulated DEGs) were obtained. The up-regulated DEGs were significantly enriched in 15 pathways and 112 GO biological processes. The down-regulated DEGs were significantly enriched in 22 pathways and 84 GO biological processes. The PPI network with 608 nodes and 2878 interactions was constructed and the subnetwork with 53 nodes and 131 interactions was also identified. The hub DEGs (TSPO, PPIB, NME1 and NME2) were extracted in this subnetwork. Conclusions:: TSPO might contribute to the liver damage and AH progression induced by mitochondrial dysfunction through oxidative stress of liver. TSPO interacted with PPIB might play important roles in liver damage in AH. The interaction between NME1 and NME2 might contribute to the transformation from AH to hepatocellular carcinoma. Twit Text FOAVip Molecular Mechanisms for Alcoholic Hepatitis Based on Analysis of Gene Expression Profile ????Hepat Mon http://www.kidney.de/pget.php?&tw=1&pmid=26045708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26045708 #FOAvip English Wikipedia <ref>{{Cite pmid|26045708}}</ref> Molecular Mechanisms for Alcoholic Hepatitis Based on Analysis of Gene Expression Profile #MMPMID26045708 Liu M; Dou Y; Sun R; Zhang Y; Liu Y Hepat Mon 2015[May]; 15 (5): ä PMID26045708show ga Background:: Alcoholic hepatitis (AH) is an acute manifestation of alcoholic liver disease with high mortality rates. Objectives:: Our aim was to study the molecular mechanisms of AH. Materials and Methods:: The differentially expressed genes (DEGs) in liver between AH and control cases were identified by analyzing the GSE28619 microarray data using t-test. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways and Gene Ontology (GO) enrichment analyses were performed using DAVID online tool. The protein-protein interaction (PPI) network was constructed using Search Tool for the Retrieval of Interacting Genes (STRING) and the subnetwork was identified by BioNet. Both PPI network and subnetwork were visualized using the Cytoscape software. Results:: Total 908 DEGs (551 up- and 357 down-regulated DEGs) were obtained. The up-regulated DEGs were significantly enriched in 15 pathways and 112 GO biological processes. The down-regulated DEGs were significantly enriched in 22 pathways and 84 GO biological processes. The PPI network with 608 nodes and 2878 interactions was constructed and the subnetwork with 53 nodes and 131 interactions was also identified. The hub DEGs (TSPO, PPIB, NME1 and NME2) were extracted in this subnetwork. Conclusions:: TSPO might contribute to the liver damage and AH progression induced by mitochondrial dysfunction through oxidative stress of liver. TSPO interacted with PPIB might play important roles in liver damage in AH. The interaction between NME1 and NME2 might contribute to the transformation from AH to hepatocellular carcinoma. äMolecular Mechanisms for Alcoholic Hepatitis Based on Analysis of Gene(epmc).pdf DeepDyve Pubget Overpricing