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10.5812/hepatmon.15(5)2015.28473 http://scihub22266oqcxt.onion/10.5812/hepatmon.15(5)2015.28473 C4451274!4451274!26045710     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hepat+Mon 2015 ; 15 (5): ä Nephropedia Template TP {{tp|p=26045710|t=2015. LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes |pdf=|usr=}}{{26045710}} gab.com Text LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes JO: Hepat Mon http://www.kidney.de/pget.php?&tw=1&pmid=26045710 #FOAvip Background:: Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-?/?), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leucine-rich repeat (in Flightless I) interacting protein-1 (LRRFIP1) was reported contributing to the production of interferon-? in macrophages. Objectives:: The aim of this study was to assess the role of LRRFIP1 in induction of IFN-? and inhibition of HCV infection in hepatocytes. Materials and Methods:: Induction of IFN-? by LRRFIP1 in Huh7 and Huh7.5.1 was determined by real-time PCR and western blotting in vitro. Inhibition of HCV replication by LRRFIP1 overexpression in hepatocytes was assessed. Results:: LRRFIP1 increased the expression of IFN-? in hepatocytes with or without HCV infection. Induction of IFN-? by LRRFIP1 was enhanced with the presence of hepatitis C virus. Overexpression of LRRFIP1 in hepatocytes inhibited HCV replication. However, HCV infection did not regulate intracellular expression of LRRFIP1. Conclusions:: LRRFIP1 and its mediated production of type I interferon play a role in controlling HCV infection. The findings of this study provide new target for HCV treatment and contribute to development of anti-HCV drugs. Twit Text FOAVip LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes ????Hepat Mon http://www.kidney.de/pget.php?&tw=1&pmid=26045710 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26045710 #FOAvip English Wikipedia <ref>{{Cite pmid|26045710}}</ref> LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes #MMPMID26045710 Liu Y; Zou Z; Zhu B; Hu Z; Zeng P; Wu L Hepat Mon 2015[May]; 15 (5): ä PMID26045710show ga Background:: Hepatitis C virus infection is one of the leading causes of end stage liver diseases. The innate immune response slows down viral replication by activating cytokines such as type I interferon (IFN-?/?), which trigger the synthesis of antiviral proteins and modulate the adaptive immune system. Recently, leucine-rich repeat (in Flightless I) interacting protein-1 (LRRFIP1) was reported contributing to the production of interferon-? in macrophages. Objectives:: The aim of this study was to assess the role of LRRFIP1 in induction of IFN-? and inhibition of HCV infection in hepatocytes. Materials and Methods:: Induction of IFN-? by LRRFIP1 in Huh7 and Huh7.5.1 was determined by real-time PCR and western blotting in vitro. Inhibition of HCV replication by LRRFIP1 overexpression in hepatocytes was assessed. Results:: LRRFIP1 increased the expression of IFN-? in hepatocytes with or without HCV infection. Induction of IFN-? by LRRFIP1 was enhanced with the presence of hepatitis C virus. Overexpression of LRRFIP1 in hepatocytes inhibited HCV replication. However, HCV infection did not regulate intracellular expression of LRRFIP1. Conclusions:: LRRFIP1 and its mediated production of type I interferon play a role in controlling HCV infection. The findings of this study provide new target for HCV treatment and contribute to development of anti-HCV drugs. äLRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Inte(epmc).pdf DeepDyve Pubget Overpricing