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10.1155/2015/712490 http://scihub22266oqcxt.onion/10.1155/2015/712490 C4451265!4451265 !26090496     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26090496 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis |pdf=|usr=}}{{26090496 }} gab.com Text The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26090496 #FOAvip The definition of posttranslational modification (PTM) encompasses a wide group of chemical reactions that allow modification and modulation of protein functions. The regulation of PTMs is crucial for the activity and survival of the cells. Dysregulation of PTMs has been observed in several pathological conditions, including rheumatoid arthritis (RA). RA is a systemic autoimmune disease primarily targeting the joints. The three PTMs mainly involved in this disease are glycosylation, citrullination, and carbamylation. Glycosylation is essential for antigen processing and presentation and can modulate immunoglobulin activity. Citrullination of self-antigens is strongly associated with RA, as demonstrated by the presence of antibodies directed to anti-citrullinated proteins in patients' sera. Carbamylation and its dysregulation have been recently associated with RA. Aim of this review is to illustrate the most significant alterations of these PTMs in RA and to evaluate their possible involvement in the pathogenesis of the disease. Twit Text FOAVip The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26090496 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26090496 #FOAvip English Wikipedia <ref>{{Cite pmid|26090496 }}</ref> The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis #MMPMID26090496 Mastrangelo A ; Colasanti T ; Barbati C ; Pecani A ; Sabatinelli D ; Pendolino M ; Truglia S ; Massaro L ; Mancini R ; Miranda F ; Spinelli FR ; Conti F ; Alessandri C J Immunol Res 2015[]; 2015 (ä): 712490 PMID26090496 show ga The definition of posttranslational modification (PTM) encompasses a wide group of chemical reactions that allow modification and modulation of protein functions. The regulation of PTMs is crucial for the activity and survival of the cells. Dysregulation of PTMs has been observed in several pathological conditions, including rheumatoid arthritis (RA). RA is a systemic autoimmune disease primarily targeting the joints. The three PTMs mainly involved in this disease are glycosylation, citrullination, and carbamylation. Glycosylation is essential for antigen processing and presentation and can modulate immunoglobulin activity. Citrullination of self-antigens is strongly associated with RA, as demonstrated by the presence of antibodies directed to anti-citrullinated proteins in patients' sera. Carbamylation and its dysregulation have been recently associated with RA. Aim of this review is to illustrate the most significant alterations of these PTMs in RA and to evaluate their possible involvement in the pathogenesis of the disease. |Animals [MESH] |Antibodies/immunology [MESH] |Antigens/immunology [MESH] |Arthritis, Rheumatoid/*immunology [MESH] |Glycosylation [MESH] |Humans [MESH]The Role of Posttranslational Protein Modifications in Rheumatological(epmc).pdf DeepDyve Pubget Overpricing