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10.1002/wrna.116

http://scihub22266oqcxt.onion/10.1002/wrna.116
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C4451228!4451228!22012871
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suck abstract from ncbi

pmid22012871      Wiley+Interdiscip+Rev+RNA 2012 ; 3 (3): 385-96
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  • Signals for pre-mRNA cleavage and polyadenylation #MMPMID22012871
  • Tian B; Graber JH
  • Wiley Interdiscip Rev RNA 2012[May]; 3 (3): 385-96 PMID22012871show ga
  • Pre-mRNA cleavage and polyadenylation is an essential step for 3? end formation of almost all protein-coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis-acting elements in the pre-mRNA surrounding the cleavage site. Experimental and bioinformatic studies in the past three decades have elucidated conserved and divergent elements across eukaryotes, from yeast to human. Here we review histories and current models of these elements in a broad range of species.
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