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10.1084/jem.20141268

http://scihub22266oqcxt.onion/10.1084/jem.20141268
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C4451130!4451130!25964372
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suck abstract from ncbi


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pmid25964372      J+Exp+Med 2015 ; 212 (6): 905-25
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  • An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode #MMPMID25964372
  • Doni A; Musso T; Morone D; Bastone A; Zambelli V; Sironi M; Castagnoli C; Cambieri I; Stravalaci M; Pasqualini F; Laface I; Valentino S; Tartari S; Ponzetta A; Maina V; Barbieri SS; Tremoli E; Catapano AL; Norata GD; Bottazzi B; Garlanda C; Mantovani A
  • J Exp Med 2015[Jun]; 212 (6): 905-25 PMID25964372show ga
  • Doni et al. use four tissue damage models in mice and find that the fluid phase pattern recognition molecule pentraxin 3 (PTX3) plays a role in tissue remodeling and repair. PTX3 binds fibrinogen/fibrin and plasminogen at an acidic pH within tissues. Mice deficient in PTX3 present defects in fibrin deposition, clot formation, collagen deposition, and macrophage-mediated fibrinolysis.
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