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10.4049/jimmunol.1403014 http://scihub22266oqcxt.onion/10.4049/jimmunol.1403014 C4451002!4451002!25934922     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (10): 4595-603 Nephropedia Template TP {{tp|p=25934922|t=2015. FcRn: The architect behind the immune and non-immune functions of IgG and albumin |pdf=|usr=}}{{25934922}} gab.com Text FcRn: The architect behind the immune and non-immune functions of IgG and albumin JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25934922 #FOAvip The neonatal Fc receptor (FcRn) belongs to the extensive and functionally divergent family of MHC molecules. Contrary to classical MHC family members, FcRn possesses little diversity and is unable to present antigens. Instead, through its capacity to bind IgG and albumin with high affinity at low pH, it regulates the serum half-lives of both of these proteins. In addition, FcRn plays important role in immunity at mucosal and systemic sites through both its ability to affect the lifespan of IgG as well as its participation in innate and adaptive immune responses. Even though the details of its biology are still emerging, the property of FcRn to rescue albumin and IgG from early degradation represents an attractive approach to alter the plasma half-life of pharmaceuticals. Here, we will review some of the most novel aspects of FcRn biology, both immune as well as non-immune, and provide some examples of FcRn-based therapies. Twit Text FOAVip FcRn: The architect behind the immune and non-immune functions of IgG and albumin ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25934922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25934922 #FOAvip English Wikipedia <ref>{{Cite pmid|25934922}}</ref> FcRn: The architect behind the immune and non-immune functions of IgG and albumin #MMPMID25934922 Pyzik M; Rath T; Lencer WI; Baker K; Blumberg RS J Immunol 2015[May]; 194 (10): 4595-603 PMID25934922show ga The neonatal Fc receptor (FcRn) belongs to the extensive and functionally divergent family of MHC molecules. Contrary to classical MHC family members, FcRn possesses little diversity and is unable to present antigens. Instead, through its capacity to bind IgG and albumin with high affinity at low pH, it regulates the serum half-lives of both of these proteins. In addition, FcRn plays important role in immunity at mucosal and systemic sites through both its ability to affect the lifespan of IgG as well as its participation in innate and adaptive immune responses. Even though the details of its biology are still emerging, the property of FcRn to rescue albumin and IgG from early degradation represents an attractive approach to alter the plasma half-life of pharmaceuticals. Here, we will review some of the most novel aspects of FcRn biology, both immune as well as non-immune, and provide some examples of FcRn-based therapies. äFcRn: The architect behind the immune and non-immune functions of IgG (epmc).pdf DeepDyve Pubget Overpricing