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10.1097/MIB.0000000000000388 http://scihub22266oqcxt.onion/10.1097/MIB.0000000000000388 C4450968!4450968 !25851564     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25851564 &cmd=llinks): Failed to open stream: HTTP request failed! 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Predicting Endoscopic Crohn s Disease Activity Before and After Induction Therapy in Children: A Comprehensive Assessment of PCDAI, CRP, and Fecal Calprotectin |pdf=|usr=}}{{25851564 }} gab.com Text Predicting Endoscopic Crohn s Disease Activity Before and After Induction Therapy in Children: A Comprehensive Assessment of PCDAI, CRP, and Fecal Calprotectin JO: Inflamm Bowel Dis http://www.kidney.de/pget.php?&tw=1&pmid=25851564 #FOAvip BACKGROUND: Mucosal healing (MH) is a vital early endpoint in management of Crohn's disease (CD). MH depends on endoscopic assessment and there is increasing interest in non-invasive proxies, Pediatric Crohn's Disease activity Index (PDCAI), C-reactive protein (CRP) and fecal calprotectin (FC). These proxies must be validated against endoscopic disease activity (SES-CD) at diagnosis and after induction therapy in well characterized cohorts of children with CD. METHODS: A prospective cohort of 24 newly diagnosed children (<16 yr) with luminal CD quantifiable on complete ileo-colonoscopy had paired PCDAI, CRP, FC and SES-CD at diagnosis and after 8 weeks therapy with exclusive enteral nutrition or steroids. RESULTS: At diagnosis: PCDAI had poor correlation (r = 0.33); CRP (r = 0.54) and FC (r = 0.46) had moderate correlation with SES-CD. After induction therapy: 11/24 had inactive disease (SES-CD 0-2); PCDAI (r = 0.34) and CRP (0.28) had poor correlation with SES-CD, many children with SES-CD ?3 having normalization of both PCDAI and CRP. FC had good correlation (r = 0.50) but many with SES-CD 0-2 had FC >200 ?g/gm stool. FC<500 (positive likelihood ratio, 3.2) and FC drop >50% (positive likelihood ratio, 3.8) had greater predictive value for inactive disease. Composite PCDAI (<10), CRP (<5 mg/dl) & FC <500 ?g had excellent Negative LR (0.2) predicting inactive disease. CONCLUSIONS: PCDAI is unreliable for endoscopic disease severity assessment. Only FC correlates with endoscopic activity after therapy but cut off <200 ?g is too high for defining endoscopic recovery in children. Composite normalized PCDAI, CRP and FC <500 ?g should be considered the non-invasive endpoint for treatment response in pediatric CD. Twit Text FOAVip Predicting Endoscopic Crohn s Disease Activity Before and After Induction Therapy in Children: A Comprehensive Assessment of PCDAI, CRP, and Fecal Calprotectin ????Inflamm Bowel Dis http://www.kidney.de/pget.php?&tw=1&pmid=25851564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25851564 #FOAvip English Wikipedia <ref>{{Cite pmid|25851564 }}</ref> Predicting Endoscopic Crohn s Disease Activity Before and After Induction Therapy in Children: A Comprehensive Assessment of PCDAI, CRP, and Fecal Calprotectin #MMPMID25851564 Zubin G ; Peter L Inflamm Bowel Dis 2015[Jun]; 21 (6 ): 1386-91 PMID25851564 show ga BACKGROUND: Mucosal healing (MH) is a vital early endpoint in management of Crohn's disease (CD). MH depends on endoscopic assessment and there is increasing interest in non-invasive proxies, Pediatric Crohn's Disease activity Index (PDCAI), C-reactive protein (CRP) and fecal calprotectin (FC). These proxies must be validated against endoscopic disease activity (SES-CD) at diagnosis and after induction therapy in well characterized cohorts of children with CD. METHODS: A prospective cohort of 24 newly diagnosed children (<16 yr) with luminal CD quantifiable on complete ileo-colonoscopy had paired PCDAI, CRP, FC and SES-CD at diagnosis and after 8 weeks therapy with exclusive enteral nutrition or steroids. RESULTS: At diagnosis: PCDAI had poor correlation (r = 0.33); CRP (r = 0.54) and FC (r = 0.46) had moderate correlation with SES-CD. After induction therapy: 11/24 had inactive disease (SES-CD 0-2); PCDAI (r = 0.34) and CRP (0.28) had poor correlation with SES-CD, many children with SES-CD ?3 having normalization of both PCDAI and CRP. FC had good correlation (r = 0.50) but many with SES-CD 0-2 had FC >200 ?g/gm stool. FC<500 (positive likelihood ratio, 3.2) and FC drop >50% (positive likelihood ratio, 3.8) had greater predictive value for inactive disease. Composite PCDAI (<10), CRP (<5 mg/dl) & FC <500 ?g had excellent Negative LR (0.2) predicting inactive disease. CONCLUSIONS: PCDAI is unreliable for endoscopic disease severity assessment. Only FC correlates with endoscopic activity after therapy but cut off <200 ?g is too high for defining endoscopic recovery in children. Composite normalized PCDAI, CRP and FC <500 ?g should be considered the non-invasive endpoint for treatment response in pediatric CD. |*Severity of Illness Index [MESH] |Adolescent [MESH] |Adrenal Cortex Hormones/therapeutic use [MESH] |Biomarkers/analysis [MESH] |C-Reactive Protein/*analysis [MESH] |Child [MESH] |Colonoscopy/*statistics & numerical data [MESH] |Crohn Disease/blood/drug therapy/*pathology [MESH] |Enteral Nutrition [MESH] |Feces/*chemistry [MESH] |Female [MESH] |Humans [MESH] |Ileum/surgery [MESH] |Induction Chemotherapy [MESH] |Leukocyte L1 Antigen Complex/*analysis [MESH] |Male [MESH] |Predictive Value of Tests [MESH] |Prospective Studies [MESH]Predicting Endoscopic Crohn s Disease Activity Before and After Induct(epmc).pdf DeepDyve Pubget Overpricing