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10.1038/srep10536 http://scihub22266oqcxt.onion/10.1038/srep10536 C4450756!4450756 !26030277     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26030277 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 10536 Nephropedia Template TP {{tp|p=26030277 |t=2015. The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-? in colitis |pdf=|usr=}}{{26030277 }} gab.com Text The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon- in colitis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26030277 #FOAvip Wnt5a, which regulates various cellular functions in Wnt signaling, is involved in inflammatory responses, however the mechanism is not well understood. We examined the role of Wnt5a signaling in intestinal immunity using conditional knockout mice for Wnt5a and its receptor Ror2. Removing Wnt5a or Ror2 in adult mice suppressed dextran sodium sulfate (DSS)-induced colitis. It also attenuated the DSS-dependent increase in inflammatory cytokine production and decreased interferon-? (IFN-?)-producing CD4(+) Th1 cell numbers in the colon. Wnt5a was highly expressed in stromal fibroblasts in ulcerative lesions in the DSS-treated mice and inflammatory bowel disease patients. Dendritic cells (DCs) isolated from the colon of Wnt5a and Ror2 deficient mice reduced the ability to differentiate naïve CD4(+) T cells to IFN-?-producing CD4(+) Th1 cells. In vitro experiments demonstrated that the Wnt5a-Ror2 signaling axis augmented the DCs priming effect of IFN-?, leading to enhanced lipopolysaccharide (LPS)-induced interleukin (IL)-12 expression. Taken together, these results suggest that Wnt5a promotes IFN-? signaling, leading to IL-12 expression in DCs, and thereby inducing Th1 differentiation in colitis. Twit Text FOAVip The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon- in colitis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26030277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26030277 #FOAvip English Wikipedia <ref>{{Cite pmid|26030277 }}</ref> The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-? in colitis #MMPMID26030277 Sato A ; Kayama H ; Shojima K ; Matsumoto S ; Koyama H ; Minami Y ; Nojima S ; Morii E ; Honda H ; Takeda K ; Kikuchi A Sci Rep 2015[Jun]; 5 (ä): 10536 PMID26030277 show ga Wnt5a, which regulates various cellular functions in Wnt signaling, is involved in inflammatory responses, however the mechanism is not well understood. We examined the role of Wnt5a signaling in intestinal immunity using conditional knockout mice for Wnt5a and its receptor Ror2. Removing Wnt5a or Ror2 in adult mice suppressed dextran sodium sulfate (DSS)-induced colitis. It also attenuated the DSS-dependent increase in inflammatory cytokine production and decreased interferon-? (IFN-?)-producing CD4(+) Th1 cell numbers in the colon. Wnt5a was highly expressed in stromal fibroblasts in ulcerative lesions in the DSS-treated mice and inflammatory bowel disease patients. Dendritic cells (DCs) isolated from the colon of Wnt5a and Ror2 deficient mice reduced the ability to differentiate naïve CD4(+) T cells to IFN-?-producing CD4(+) Th1 cells. In vitro experiments demonstrated that the Wnt5a-Ror2 signaling axis augmented the DCs priming effect of IFN-?, leading to enhanced lipopolysaccharide (LPS)-induced interleukin (IL)-12 expression. Taken together, these results suggest that Wnt5a promotes IFN-? signaling, leading to IL-12 expression in DCs, and thereby inducing Th1 differentiation in colitis. |*Signal Transduction [MESH] |Animals [MESH] |Bone Marrow/metabolism [MESH] |Colitis/chemically induced/genetics/*metabolism [MESH] |Cytokines/metabolism [MESH] |Dendritic Cells/immunology/metabolism [MESH] |Dextran Sulfate/adverse effects [MESH] |Disease Models, Animal [MESH] |Disease Susceptibility [MESH] |Fibroblasts/metabolism [MESH] |Gene Expression [MESH] |Inflammation Mediators/metabolism [MESH] |Interferon-gamma/*metabolism [MESH] |Interleukin-12/*metabolism [MESH] |Intestinal Mucosa/metabolism/pathology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Organ Specificity/genetics [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Receptor Tyrosine Kinase-like Orphan Receptors/genetics/*metabolism [MESH] |Wnt Proteins/genetics/*metabolism [MESH]The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin(epmc).pdf DeepDyve Pubget Overpricing