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http://scihub22266oqcxt.onion/ C4450672!4450672!2988123     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 1985 ; 228 (4701): 815-22 Nephropedia Template TP {{tp|p=2988123|t=1985. The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins |pdf=|usr=}}{{2988123}} gab.com Text The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=2988123 #FOAvip The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains, we have determined the exon organization of the gene for the low-density lipoprotein (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of which correlate with functional domains previously defined at the protein level. Thirteen of the 18 exons encode protein sequences that are homologous to sequences in other proteins: five of these exons encode a sequence similar to one in the C9 component of complement; three exons encode a sequence similar to a repeat sequence in the precursor for epidermal growth factor (EGF) and in three proteins of the blood clotting system (factor IX, factor X, and protein C); and five other exons encode nonrepeated sequences that are shared only with the EGF precursor. The LDL receptor appears to be a mosaic protein built up of exons shared with different proteins, and it therefore belongs to several supergene families. Twit Text FOAVip The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins ????Science http://www.kidney.de/pget.php?&tw=1&pmid=2988123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=2988123 #FOAvip English Wikipedia <ref>{{Cite pmid|2988123}}</ref> The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins #MMPMID2988123 Südhof TC; Goldstein JL; Brown MS; Russell DW Science 1985[May]; 228 (4701): 815-22 PMID2988123show ga The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains, we have determined the exon organization of the gene for the low-density lipoprotein (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of which correlate with functional domains previously defined at the protein level. Thirteen of the 18 exons encode protein sequences that are homologous to sequences in other proteins: five of these exons encode a sequence similar to one in the C9 component of complement; three exons encode a sequence similar to a repeat sequence in the precursor for epidermal growth factor (EGF) and in three proteins of the blood clotting system (factor IX, factor X, and protein C); and five other exons encode nonrepeated sequences that are shared only with the EGF precursor. The LDL receptor appears to be a mosaic protein built up of exons shared with different proteins, and it therefore belongs to several supergene families. äThe LDL Receptor Gene: A Mosaic of Exons Shared with Different Protein(epmc).pdf DeepDyve Pubget Overpricing