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2015 ; 6
(ä): 493
Nephropedia Template TP
Front Microbiol
2015[]; 6
(ä): 493
PMID26082756
show ga
The ultimate aim of the immune system is to eliminate pathogens without being
harmful to the host. But what if eliminating the pathogen in itself is
discomforting for the host? One such emerging case is of Helicobacter pylori.
Modern medicine, infantile vaccination, and ultra-hygienic conditions have led to
progressive disappearance of H. pylori in different parts of the world. However,
the adversities caused by H. pylori's absence are much larger than those caused
by its presence. Asthma is rising as an epidemic in last few decades and several
reports suggest an inverse-relationship between H. pylori's persistence and
early-life onset asthma. Regulatory T cells play an important role in both the
cases. This is further supported by experiments on mouse-models. Hence, need of
the hour is to discern the relationship between H. pylori and its host and
eliminating its negative impacts without disturbing our indigenous microbiota. To
resolve whether H. pylori is a pathogen or an amphibiont is another important
side. This review explores the biological basis of H. pylori-induced priming of
immune system offering resistance to childhood-onset asthma. HP-NAP-Tregs
interaction has been predicted using molecular docking and dynamic simulation.