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10.1186/s13287-015-0089-y http://scihub22266oqcxt.onion/10.1186/s13287-015-0089-y C4450459!4450459!26028404     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stem+Cell+Res+Ther 2015 ; 6 (1): ä Nephropedia Template TP {{tp|p=26028404|t=2015. Current achievements and future perspectives in whole-organ bioengineering |pdf=|usr=}}{{26028404}} gab.com Text Current achievements and future perspectives in whole-organ bioengineering JO: Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26028404 #FOAvip Irreversible end-stage organ failure represents one of the leading causes of death, and organ transplantation is currently the only curative solution. Donor organ shortage and adverse effects of immunosuppressive regimens are the major limiting factors for this definitive practice. Recent developments in bioengineering and regenerative medicine could provide a solid base for the future creation of implantable, bioengineered organs. Whole-organ detergent-perfusion protocols permit clinicians to gently remove all the cells and at the same time preserve the natural three-dimensional framework of the native organ. Several decellularized organs, including liver, kidney, and pancreas, have been created as a platform for further successful seeding. These scaffolds are composed of organ-specific extracellular matrix that contains growth factors important for cellular growth and function. Macro- and microvascular tree is entirely maintained and can be incorporated in the recipient?s vascular system after the implant. This review will emphasize recent achievements in the whole-organ scaffolds and at the same time underline complications that the scientific community has to resolve before reaching a functional bioengineered organ. Twit Text FOAVip Current achievements and future perspectives in whole-organ bioengineering ????Stem Cell Res Ther http://www.kidney.de/pget.php?&tw=1&pmid=26028404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028404 #FOAvip English Wikipedia <ref>{{Cite pmid|26028404}}</ref> Current achievements and future perspectives in whole-organ bioengineering #MMPMID26028404 Peloso A; Dhal A; Zambon JP; Li P; Orlando G; Atala A; Soker S Stem Cell Res Ther 2015[]; 6 (1): ä PMID26028404show ga Irreversible end-stage organ failure represents one of the leading causes of death, and organ transplantation is currently the only curative solution. Donor organ shortage and adverse effects of immunosuppressive regimens are the major limiting factors for this definitive practice. Recent developments in bioengineering and regenerative medicine could provide a solid base for the future creation of implantable, bioengineered organs. Whole-organ detergent-perfusion protocols permit clinicians to gently remove all the cells and at the same time preserve the natural three-dimensional framework of the native organ. Several decellularized organs, including liver, kidney, and pancreas, have been created as a platform for further successful seeding. These scaffolds are composed of organ-specific extracellular matrix that contains growth factors important for cellular growth and function. Macro- and microvascular tree is entirely maintained and can be incorporated in the recipient?s vascular system after the implant. This review will emphasize recent achievements in the whole-organ scaffolds and at the same time underline complications that the scientific community has to resolve before reaching a functional bioengineered organ. äCurrent achievements and future perspectives in whole-organ bioenginee(epmc).pdf DeepDyve Pubget Overpricing