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10.1038/bcj.2015.25 http://scihub22266oqcxt.onion/10.1038/bcj.2015.25 C4450325!4450325!25885425     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood+Cancer+J 2015 ; 5 (4): e304- Nephropedia Template TP {{tp|p=25885425|t=2015. Acute promyelocytic leukemia: where did we start, where are we now, and the future |pdf=|usr=}}{{25885425}} gab.com Text Acute promyelocytic leukemia: where did we start, where are we now, and the future JO: Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25885425 #FOAvip Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction of ATRA initially as a single agent and then in combination with anthracyclines, and more recently by development of arsenic trioxide (ATO)-containing regimens, APL is now characterized by complete remission rates of 90% and cure rates of ?80%, even higher among low-risk patients. Furthermore, with ATRA?ATO combinations, chemotherapy may safely be omitted in low-risk patients. The disease is now considered to be the most curable subtype of acute myeloid leukemia (AML) in adults. Nevertheless, APL remains associated with a significant incidence of early death related to the characteristic bleeding diathesis. Early death, rather than resistant disease so common in all other subtypes of AML, has emerged as the major cause of treatment failure. Twit Text FOAVip Acute promyelocytic leukemia: where did we start, where are we now, and the future ????Blood Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25885425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25885425 #FOAvip English Wikipedia <ref>{{Cite pmid|25885425}}</ref> Acute promyelocytic leukemia: where did we start, where are we now, and the future #MMPMID25885425 Coombs CC; Tavakkoli M; Tallman MS Blood Cancer J 2015[Apr]; 5 (4): e304- PMID25885425show ga Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all-trans retinoic acid (ATRA). With considerable advances in therapy, including the introduction of ATRA initially as a single agent and then in combination with anthracyclines, and more recently by development of arsenic trioxide (ATO)-containing regimens, APL is now characterized by complete remission rates of 90% and cure rates of ?80%, even higher among low-risk patients. Furthermore, with ATRA?ATO combinations, chemotherapy may safely be omitted in low-risk patients. The disease is now considered to be the most curable subtype of acute myeloid leukemia (AML) in adults. Nevertheless, APL remains associated with a significant incidence of early death related to the characteristic bleeding diathesis. Early death, rather than resistant disease so common in all other subtypes of AML, has emerged as the major cause of treatment failure. äAcute promyelocytic leukemia: where did we start, where are we now, an(epmc).pdf DeepDyve Pubget Overpricing