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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Arthritis+Rheumatol
2015 ; 67
(4
): 988-99
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Circulating follicular helper-like T cells in systemic lupus erythematosus:
association with disease activity
#MMPMID25581113
Choi JY
; Ho JH
; Pasoto SG
; Bunin V
; Kim ST
; Carrasco S
; Borba EF
; Gonçalves CR
; Costa PR
; Kallas EG
; Bonfa E
; Craft J
Arthritis Rheumatol
2015[Apr]; 67
(4
): 988-99
PMID25581113
show ga
OBJECTIVE: To assess circulating follicular helper T (Tfh)-like CD4+ T cells in
patients with systemic lupus erythematosus (SLE) and determine their relationship
to disease activity. METHODS: Blood samples from patients with SLE, as well as
blood samples from patients with Behçet's disease (BD) and healthy individuals as
controls, were analyzed. In all samples, circulating Tfh-like cells were
enumerated by flow cytometry, using, as markers, expression of CXCR5, inducible T
cell costimulator (ICOS), and programmed death 1 (PD-1) protein, as well as
secretion of interleukin-21 (IL-21). The frequency of circulating Tfh-like cells
was compared to that of circulating plasmablasts (CD19+IgD-CD38+). In addition,
the possible association of circulating Tfh-like cells with the SLE Disease
Activity Index (SLEDAI) was evaluated. RESULTS: The subset of circulating
Tfh-like T cells, identified as CXCR5(high) ICOS(high) PD-1(high) , was expanded
in the blood of SLE patients compared to controls. Circulating Tfh-like cells
were found to produce IL-21 and had lower expression of CCR7 as compared to that
in circulating CXCR5(high) central memory T cells, thereby enabling their
distinction. Expression of PD-1, but not ICOS or CXCR5, was significantly
elevated in circulating Tfh-like cells from SLE patients compared to controls.
PD-1 expression among CXCR5(high) circulating Tfh-like cells correlated with the
SLEDAI, frequency of circulating plasmablasts, and anti-double-stranded DNA
antibody positivity, but not with disease duration or past organ injury; rather,
this cell profile appeared to be a reflection of current active disease.
CONCLUSION: Circulating Tfh-like cells are associated with disease activity in
SLE, suggesting that their presence indicates abnormal homeostasis of T cell-B
cell collaboration, with a causal relationship that is central to disease
pathogenesis. These findings also suggest that circulating Tfh-like cells provide
a surrogate for aberrant germinal center activity in SLE, and that their PD-1
expression offers a tool for measuring disease activity and monitoring the
response to therapies.
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