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10.1089/ars.2015.6322 http://scihub22266oqcxt.onion/10.1089/ars.2015.6322 C4449713!4449713!25808102     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxid+Redox+Signal 2015 ; 22 (17): 1527-44 Nephropedia Template TP {{tp|p=25808102|t=2015. Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy |pdf=|usr=}}{{25808102}} gab.com Text Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=25808102 #FOAvip Significance: Diabetes is strongly associated with increased incidence of heart disease and mortality due to development of diabetic cardiomyopathy. Even in the absence of cardiovascular disease, cardiomyopathy frequently arises in diabetic patients. Current treatment options for cardiomyopathy in diabetic patients are the same as for nondiabetic patients and do not address the causes underlying the loss of contractility. Recent Advances: Although there are numerous distinctions between Type 1 and Type 2 diabetes, recent evidence suggests that the two disease states converge on mitochondria as an epicenter for cardiomyocyte damage. Critical Issues: Accumulation of dysfunctional mitochondria contributes to cardiac tissue injury in both acute and chronic conditions. Removal of damaged mitochondria by macroautophagy, termed ?mitophagy,? is critical for maintaining cardiomyocyte health and contractility both under normal conditions and during stress. However, very little is known about the involvement of mitophagy in the pathogenesis of diabetic cardiomyopathy. A growing interest in this topic has given rise to a wave of publications that aim at deciphering the status of autophagy and mitophagy in Type 1 and Type 2 diabetes. Future Directions: This review summarizes these recent studies with the goal of drawing conclusions about the activation or suppression of autophagy and mitophagy in the diabetic heart. A better understanding of how autophagy and mitophagy are affected in the diabetic myocardium is still needed, as well as whether they can be targeted therapeutically. Antioxid. Redox Signal. 22, 1527?1544. Twit Text FOAVip Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=25808102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25808102 #FOAvip English Wikipedia <ref>{{Cite pmid|25808102}}</ref> Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy #MMPMID25808102 Kubli DA; Gustafsson ÅB Antioxid Redox Signal 2015[Jun]; 22 (17): 1527-44 PMID25808102show ga Significance: Diabetes is strongly associated with increased incidence of heart disease and mortality due to development of diabetic cardiomyopathy. Even in the absence of cardiovascular disease, cardiomyopathy frequently arises in diabetic patients. Current treatment options for cardiomyopathy in diabetic patients are the same as for nondiabetic patients and do not address the causes underlying the loss of contractility. Recent Advances: Although there are numerous distinctions between Type 1 and Type 2 diabetes, recent evidence suggests that the two disease states converge on mitochondria as an epicenter for cardiomyocyte damage. Critical Issues: Accumulation of dysfunctional mitochondria contributes to cardiac tissue injury in both acute and chronic conditions. Removal of damaged mitochondria by macroautophagy, termed ?mitophagy,? is critical for maintaining cardiomyocyte health and contractility both under normal conditions and during stress. However, very little is known about the involvement of mitophagy in the pathogenesis of diabetic cardiomyopathy. A growing interest in this topic has given rise to a wave of publications that aim at deciphering the status of autophagy and mitophagy in Type 1 and Type 2 diabetes. Future Directions: This review summarizes these recent studies with the goal of drawing conclusions about the activation or suppression of autophagy and mitophagy in the diabetic heart. A better understanding of how autophagy and mitophagy are affected in the diabetic myocardium is still needed, as well as whether they can be targeted therapeutically. Antioxid. Redox Signal. 22, 1527?1544. äUnbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardio(epmc).pdf DeepDyve Pubget Overpricing