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2014 ; 3
(2
): 663-78
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Microarray Technology for the Diagnosis of Fetal Chromosomal Aberrations: Which
Platform Should We Use?
#MMPMID26237396
Karampetsou E
; Morrogh D
; Chitty L
J Clin Med
2014[Jun]; 3
(2
): 663-78
PMID26237396
show ga
The advantage of microarray (array) over conventional karyotype for the diagnosis
of fetal pathogenic chromosomal anomalies has prompted the use of microarrays in
prenatal diagnostics. In this review we compare the performance of different
array platforms (BAC, oligonucleotide CGH, SNP) and designs (targeted, whole
genome, whole genome, and targeted, custom) and discuss their advantages and
disadvantages in relation to prenatal testing. We also discuss the factors to
consider when implementing a microarray testing service for the diagnosis of
fetal chromosomal aberrations.