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10.3390/jcm3020646 http://scihub22266oqcxt.onion/10.3390/jcm3020646 C4449690!4449690!26237395     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Med 2014 ; 3 (2): 646-62 Nephropedia Template TP {{tp|p=26237395|t=2014. Roles of Sphingolipid Metabolism in Pancreatic ? Cell Dysfunction Induced by Lipotoxicity |pdf=|usr=}}{{26237395}} gab.com Text Roles of Sphingolipid Metabolism in Pancreatic Cell Dysfunction Induced by Lipotoxicity JO: J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237395 #FOAvip Pancreatic ? cells secrete insulin in order to maintain glucose homeostasis. However, various environmental stresses such as obesity have been shown to induce loss of secretory responsiveness in pancreatic ? cells and pancreatic ? cell apoptosis which can favor the development of type 2 diabetes (T2D). Indeed, elevated levels of free fatty acids (FFAs) have been shown to induce ? cell apoptosis. Importantly, the chronic adverse effects of FFAs on ? cell function and viability are potentiated in the presence of hyperglycaemia, a phenomenon that has been termed gluco-lipotoxicity. The molecular mechanisms underlying the pathogenesis of gluco-lipotoxicity in pancreatic ? cells are not completely understood. Recent studies have shown that sphingolipid metabolism plays a key role in gluco-lipotoxicity induced apoptosis and loss of function of pancreatic ? cells. The present review focuses on how the two main sphingolipid mediators, ceramides and sphingoid base-1-phosphates, regulate the deleterious effects of gluco-lipotoxicity on pancreatic ? cells. The review highlights the role of a sphingolipid biostat on the dysregulation of ? cell fate and function induced by gluco-lipotoxicity, offering the possibility of new therapeutic targets to prevent the onset of T2D. Twit Text FOAVip Roles of Sphingolipid Metabolism in Pancreatic Cell Dysfunction Induced by Lipotoxicity ????J Clin Med http://www.kidney.de/pget.php?&tw=1&pmid=26237395 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26237395 #FOAvip English Wikipedia <ref>{{Cite pmid|26237395}}</ref> Roles of Sphingolipid Metabolism in Pancreatic ? Cell Dysfunction Induced by Lipotoxicity #MMPMID26237395 Véret J; Bellini L; Giussani P; Ng C; Magnan C; Le Stunff H J Clin Med 2014[Jun]; 3 (2): 646-62 PMID26237395show ga Pancreatic ? cells secrete insulin in order to maintain glucose homeostasis. However, various environmental stresses such as obesity have been shown to induce loss of secretory responsiveness in pancreatic ? cells and pancreatic ? cell apoptosis which can favor the development of type 2 diabetes (T2D). Indeed, elevated levels of free fatty acids (FFAs) have been shown to induce ? cell apoptosis. Importantly, the chronic adverse effects of FFAs on ? cell function and viability are potentiated in the presence of hyperglycaemia, a phenomenon that has been termed gluco-lipotoxicity. The molecular mechanisms underlying the pathogenesis of gluco-lipotoxicity in pancreatic ? cells are not completely understood. Recent studies have shown that sphingolipid metabolism plays a key role in gluco-lipotoxicity induced apoptosis and loss of function of pancreatic ? cells. The present review focuses on how the two main sphingolipid mediators, ceramides and sphingoid base-1-phosphates, regulate the deleterious effects of gluco-lipotoxicity on pancreatic ? cells. The review highlights the role of a sphingolipid biostat on the dysregulation of ? cell fate and function induced by gluco-lipotoxicity, offering the possibility of new therapeutic targets to prevent the onset of T2D. äRoles of Sphingolipid Metabolism in Pancreatic ? Cell Dysfunction Indu(epmc).pdf DeepDyve Pubget Overpricing