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10.3390/jcm3030809

http://scihub22266oqcxt.onion/10.3390/jcm3030809
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C4449651!4449651!26237479
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suck abstract from ncbi


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pmid26237479      J+Clin+Med 2014 ; 3 (3): 809-37
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  • Chromosomal Mosaicism in Human Feto-Placental Development: Implications for Prenatal Diagnosis #MMPMID26237479
  • Grati FR
  • J Clin Med 2014[Sep]; 3 (3): 809-37 PMID26237479show ga
  • Chromosomal mosaicism is one of the primary interpretative issues in prenatal diagnosis. In this review, the mechanisms underlying feto-placental chromosomal mosaicism are presented. Based on the substantial retrospective diagnostic experience with chorionic villi samples (CVS) of a prenatal diagnosis laboratory the following items are discussed: (i) The frequency of the different types of mosaicism (confined placental, CPM, and true fetal mosaicisms, TFM); (ii) The risk of fetal confirmation after the detection of a mosaic in CVS stratified by chromosome abnormality and placental tissue involvement; (iii) The frequency of uniparental disomy for imprinted chromosomes associated with CPM; (iv) The incidence of false-positive and false-negative results in CVS samples analyzed by only (semi-)direct preparation or long term culture; and (v) The implications of the presence of a feto-placental mosaicism for microarray analysis of CVS and non-invasive prenatal screening (NIPS).
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