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Actual Therapeutic Indication of an Old Drug: Urea for Treatment of Severely
Symptomatic and Mild Chronic Hyponatremia Related to SIADH
#MMPMID26237492
Decaux G
; Gankam Kengne F
; Couturier B
; Vandergheynst F
; Musch W
; Soupart A
J Clin Med
2014[Sep]; 3
(3
): 1043-9
PMID26237492
show ga
Oral urea has been used in the past to treat various diseases like gastric
ulcers, liver metastases, sickle cell disease, heart failure, brain oedema,
glaucoma, Meniere disease, etc. We have demonstrated for years, the efficacy of
urea to treat euvolemic (SIADH) or hypervolemic hyponatremia. We briefly describe
the indications of urea use in symptomatic and paucisymptomatic hyponatremic
patients. Urea is a non-toxic, cheap product, and protects against osmotic
demyelinating syndrome (ODS) in experimental studies. Prospective studies showing
the benefit to treat mild chronic hyponatremia due to SIADH and comparing water
restriction, urea, high ceiling diuretics, and antivasopressin antagonist
antagonist should be done.