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10.1089/ars.2015.6311 http://scihub22266oqcxt.onion/10.1089/ars.2015.6311 C4449624!4449624 !25836025     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25836025 &cmd=llinks): Failed to open stream: HTTP request failed! 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Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome |pdf=|usr=}}{{25836025 }} gab.com Text Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome JO: Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=25836025 #FOAvip SIGNIFICANCE: Several authors have proposed a link between altered cardiac energy substrate metabolism and reactive oxygen species (ROS) generation. A cogent evidence of this association has been found in diabetic cardiomyopathy (dCM); however, experimental findings in animal models of heart failure (HF) and in human myocardium also seem to support the coexistence of the two alterations in HF. CRITICAL ISSUES: Two important questions remain open: whether pathological changes in metabolism play an important role in enhancing oxidative stress and whether there is a common pathway linking altered substrate utilization and activation of ROS-generating enzymes, independently of the underlying cardiac pathology. In this regard, the comparison between dCM and HF is intriguing, in that these pathological conditions display very different cardiac metabolic phenotypes. RECENT ADVANCES: Our literature review on this topic indicates that a vast body of knowledge is now available documenting the relationship between the metabolism of energy substrates and ROS generation in dCM. In some cases, biochemical mechanisms have been identified. On the other hand, only a few and relatively recent studies have explored this phenomenon in HF and their conclusions are not consistent. FUTURE DIRECTIONS: Better methods of investigation, especially in vivo, will be necessary to test whether the metabolic fate of certain substrates is causally linked to ROS production. If successful, these studies will place a new emphasis on the potential clinical relevance of metabolic modulators, which might indirectly mitigate cardiac oxidative stress in dCM, HF, and, possibly, in other pathological conditions. Twit Text FOAVip Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome ????Antioxid Redox Signal http://www.kidney.de/pget.php?&tw=1&pmid=25836025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25836025 #FOAvip English Wikipedia <ref>{{Cite pmid|25836025 }}</ref> Metabolic alterations induce oxidative stress in diabetic and failing hearts: different pathways, same outcome #MMPMID25836025 Roul D ; Recchia FA Antioxid Redox Signal 2015[Jun]; 22 (17 ): 1502-14 PMID25836025 show ga SIGNIFICANCE: Several authors have proposed a link between altered cardiac energy substrate metabolism and reactive oxygen species (ROS) generation. A cogent evidence of this association has been found in diabetic cardiomyopathy (dCM); however, experimental findings in animal models of heart failure (HF) and in human myocardium also seem to support the coexistence of the two alterations in HF. CRITICAL ISSUES: Two important questions remain open: whether pathological changes in metabolism play an important role in enhancing oxidative stress and whether there is a common pathway linking altered substrate utilization and activation of ROS-generating enzymes, independently of the underlying cardiac pathology. In this regard, the comparison between dCM and HF is intriguing, in that these pathological conditions display very different cardiac metabolic phenotypes. RECENT ADVANCES: Our literature review on this topic indicates that a vast body of knowledge is now available documenting the relationship between the metabolism of energy substrates and ROS generation in dCM. In some cases, biochemical mechanisms have been identified. On the other hand, only a few and relatively recent studies have explored this phenomenon in HF and their conclusions are not consistent. FUTURE DIRECTIONS: Better methods of investigation, especially in vivo, will be necessary to test whether the metabolic fate of certain substrates is causally linked to ROS production. If successful, these studies will place a new emphasis on the potential clinical relevance of metabolic modulators, which might indirectly mitigate cardiac oxidative stress in dCM, HF, and, possibly, in other pathological conditions. |*Energy Metabolism [MESH] |*Metabolic Networks and Pathways [MESH] |*Oxidative Stress [MESH] |Animals [MESH] |Diabetic Cardiomyopathies/*metabolism [MESH] |Heart Failure/*metabolism [MESH] |Humans [MESH] |Myocardium/metabolism/pathology [MESH]Metabolic alterations induce oxidative stress in diabetic and failing (epmc).pdf DeepDyve Pubget Overpricing