Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26060447
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26060447
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Biomed+Res
2015 ; 29
(3
): 232-40
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via
the caspase 8 pathway initiated by Fas signaling
#MMPMID26060447
Yang X
; Sun B
; Wang H
; Yin C
; Wang X
; Ji X
J Biomed Res
2015[May]; 29
(3
): 232-40
PMID26060447
show ga
We sought to investigate the expression of Fas and FasL on T cell surface and
caspase 8 involvement in T cell apoptosis promoted by serum IL-10 in systemic
lupus erythematosus (SLE) patients. Cells and sera were obtained from 35 SLE
patients. Apoptosis of T cells in patients with SLE was increased and associated
with the SLE disease activity index (SLEDAI). Elevated expression of Fas and FasL
on T cell surface contributed to increased apoptosis of T cells. Increased IL-10
in the sera of SLE patients was capable of inducing Fas and FasL expression on
CD4(+)T cell surface, promoting apoptosis of this cell subset. Decreased IL-10
serum levels and low expression of Fas were found in 5 patients of the first
follow-up group after 2-month treatment. In another group with one-year
treatment, the SLEDAI declined to inactive scores. Serum IL-10 was decreased
significantly, and expression of Fas and FasL on T cells was also reduced.
Declined apoptosis was predominant only in CD4(+)T cell subset. When sera with
high level of IL-10 were used to culture PBMCs from healthy controls, activated
caspase 8 was elevated in CD3(+)T, CD4(+)T and CD8(+)T cells. The study showed
that serum IL-10 induced apoptosis of T cell subsets via the caspase 8 pathway
initiated by Fas signaling. Increased apoptosis of T cells contributes to
autoantigen burden, which is pathogenic in the development of SLE.