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2015 ; 70
(5
): 346-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The reduction of serum aminotransferase levels is proportional to the decline of
the glomerular filtration rate in patients with chronic kidney disease
#MMPMID26039951
Sette LH
; Lopes EP
Clinics (Sao Paulo)
2015[May]; 70
(5
): 346-9
PMID26039951
show ga
OBJECTIVE: This study sought to determine the serum aminotransferase levels of
patients with predialysis chronic kidney disease and establish their
relationships with serum creatinine levels and glomerular filtration rate.
METHODS: Patients with chronic kidney disease were evaluated between September
2011 and May 2012. Aminotransferase and creatinine serum levels were measured
using an automated kinetic method, and glomerular filtration rates were estimated
using the Cockroft-Gault and Modification of Diet in Renal Disease formulas to
classify patients into chronic kidney disease stages. RESULTS: Exactly 142
patients were evaluated (mean age: 64±16 years). The mean creatinine serum level
and glomerular filtration rate were 3.3±1.2 mg/dL and 29.1±13 mL/min/1.73 m2,
respectively. Patients were distributed according to their chronic kidney disease
stages as follows: 3 (2.1%) patients were Stage 2; 54 (38%) were Stage 3; 70
(49.3%) were Stage 4; and 15 (10.5%) were Stage 5. The mean aspartate
aminotransferase and alanine aminotransferase serum levels showed a reduction in
proportion to the increase in creatinine levels (p=0.001 and p=0.05,
respectively) and the decrease in glomerular filtration rate (p=0.007 and
p=0.028, respectively). Alanine aminotransferase and aspartate aminotransferase
serum levels tended to be higher among patients classified as stage 2 or 3
compared with those classified as stage 4 or 5 (p=0.08 and p=0.06, respectively).
CONCLUSIONS: The aspartate aminotransferase and alanine aminotransferase serum
levels of patients with predialysis chronic kidney disease decreased in
proportion to the progression of the disease; they were negatively correlated
with creatinine levels and directly correlated with glomerular filtration rate.