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2015 ; 5
(3
): 1190-8
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Elevated expression of HABP1 is correlated with metastasis and poor survival in
breast cancer patients
#MMPMID26045997
Niu M
; Sun S
; Zhang G
; Zhao Y
; Pang D
; Chen Y
Am J Cancer Res
2015[]; 5
(3
): 1190-8
PMID26045997
show ga
Hyaluronan-binding protein 1 (HABP1) is a protein with high affinity for HA, and
has been reported to be upregulated in cancer cells. In this study, we show that
silencing HABP1 inhibits proliferation, and suppresses the migration and invasion
ability of breast cancer cell lines. In addition, silencing HABP1 remarkably
slows down tumor growth in mice. We examined the correlation between HABP1
expression and clinicopathological parameters using immunohistochemistry in
patients with breast cancer. The results indicate that HABP1 is overexpressed in
cancer tissue, and its high levels are related to lymph node metastasis (P =
0.032) and tumor stage (P = 0.041). Moreover, high HABP1 expression is correlated
with poor overall survival in breast cancer patients (P = 0.018), and is a
signifi cant independent prognostic indicator. Our fi ndings suggest that HABP1
regulates proliferation and migration of breast cancer cells. HABP1 may be a
useful independent predictor of outcomes in patients with breast cancer.